Cone morphometrics and contrast sensitivity in high myopia

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review


Purpose : Excessive eyeball elongation leads to various changes in retinal structures and visual functions, as characterized by the chorioretinal thinning, enlarged photoreceptors spacing, and declined contrast sensitivity. This study compared the cone morphometrics and contrast sensitivity at central and mid-peripheral retina between highly myopic and emmetropic eyes, and investigated the relationships between structural and functional changes.

Methods : Thirty-six healthy adults aged 19 to 41 years were recruited, including 17 high myopes (HM, ≤ -8.00D) and 19 emmetropes (EM, -0.50 to +0.50D). Monocular contrast detection thresholds of vertical sinusoidal gratings (spatial frequency at 0°: 1, 2, 4, 8, and 16 c/deg; 10°: 0.5, 1, 2, 4 and 8 c/deg) were measured at central and 10° temporal retina, by 3-down-1-up staircases using 2-interval-forced-choice paradigms. After log transformation, the contrast sensitivity (i.e., a reciprocal of contrast detection threshold) was fitted with symmetric parabolic function to calculate the area under the curve (AUC). Cone morphometrics (i.e., density, cell spacing, regularity, dispersion) at fovea (1.5° to 2°) and 10° temporal retina were determined from the retinal images captured by the adaptive optics retinal camera using customized Matlab software with ocular magnification corrected.

Results : The contrast sensitivity at central vision was comparable in HM and EM, as suggested by comparable AUC in two groups (2.16 vs. 2.27 log unit, p=0.248). In contrast, HM exhibited a general reduction of contrast sensitivity at 10° peripheral vision, with smaller AUC than EM (1.72 vs. 1.89 log unit, p=0.037). For the cone morphometrics, HM had lower cone density (2011.80 vs. 2396.09 cells/deg2, p=0.002) and regularity (91.10% vs. 93.15%, p=0.019), but increased cell spacing (1.50 vs. 1.38 arcmin, p=0.019) and dispersion (13.97% vs. 11.83%, p
Conclusions : Eyeball elongation affected the cone morphometrics at both foveal and mid-peripheral retina diversely. However, retinal function in terms of contrast sensitivity was preserved at central vision but was less resistant to high myopia at mid-periphery.
Original languageEnglish
Title of host publicationInvestigative Ophthalmology & Visual Science
ISBN (Electronic)1552-5783
Publication statusPublished - Jun 2022
EventAssociation for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022 - Denver, United States
Duration: 1 May 20224 May 2022


ConferenceAssociation for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022
Abbreviated titleARVO 2022
Country/TerritoryUnited States


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