Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage

T. Virén, Y. P. Huang, S. Saarakkala, H. Pulkkinen, V. Tiitu, A. Linjama, I. Kiviranta, M. J. Lammi, A. Brnott, H. Brommer, R. Van Weeren, P. A J Brama, Yongping Zheng, J. S. Jurvelin, J. Töyrs

Research output: Journal article publicationJournal articleAcademic researchpeer-review

29 Citations (Scopus)

Abstract

The aim of this study was to compare sensitivity of ultrasound and optical coherence tomography (OCT) techniques for the evaluation of the integrity of spontaneously repaired horse cartilage. Articular surfaces of horse intercarpal joints, featuring both intact tissue and spontaneously healed chondral or osteochondral defects, were imaged ex vivo with arthroscopic ultrasound and laboratory OCT devices. Quantitative ultrasound (integrated reflection coefficient (IRC), apparent integrated backscattering coefficient (AIB) and ultrasound roughness index (URI)) and optical parameters (optical reflection coefficient (ORC), optical roughness index (ORI) and optical backscattering (OBS)) were determined and compared with histological integrity and mechanical properties of the tissue. Spontaneously healed tissue could be quantitatively discerned from the intact tissue with ultrasound and OCT techniques. Furthermore, several significant correlations (p<0.05) were detected between ultrasound and OCT parameters. Superior resolution of OCT provided a more accurate measurement of cartilage surface roughness, while the ultrasound backscattering from the inner structures of the cartilage matched better with the histological findings. Since the techniques were found to be complementary to each other, dual modality imaging techniques could provide a useful tool for the arthroscopic evaluation of the integrity of articular cartilage.
Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalJournal of Medical Engineering and Technology
Volume36
Issue number3
DOIs
Publication statusPublished - 1 Apr 2012

Keywords

  • Articular cartilage
  • Cartilage repair
  • High-frequency ultrasound
  • Optical coherence tomography
  • Quantitative characterization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

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