Comparing sleep patterns between children with autism spectrum disorder and children with typical development: A matched case-control study.

Children with autism spectrum disorder are often reported to have more sleep deficits and poorer sleep quality compared
with children with typical development. However, most previous studies have serious methodological limitations, such
as varying sample sizes in the comparison groups, wide age range of participants, and body mass index not matched
between participants. This study investigated whether sleep patterns differed between children with autism spectrum
disorder and those with typical development using a carefully matched case–control design and incorporating both
actigraphy and sleep log assessments. A total of 78 children diagnosed with autism spectrum disorder were matched
with 78 typical development controls in this study. The matched variables included age, gender, and body mass index.
The results showed that children with autism spectrum disorder had shorter sleep duration, reduced sleep efficiency,
longer sleep-onset latency, and longer wake after sleep onset than children with typical development (ps < 0.05). Further
studies are needed to explore the mechanisms underlying these sleep deficits in children with autism spectrum disorder.