TY - JOUR
T1 - Combination of noninvasive brain stimulation and constraint-induced movement therapy in patients with stroke
T2 - a systematic review and meta-analysis
AU - Abdullahi, Auwal
AU - Wong, Thomson W.L.
AU - Van Criekinge, Tamaya
AU - Ng, Shamay S.M.
N1 - Funding Information:
This work was supported by research funding from the Research Centre for Chinese Medicine Innovation of the Hong Kong Polytechnic University (Ref No. P0041139) awarded to Professor S Ng and her team and by the PolyU Distinguished Postdoctoral Fellowship Scheme.
Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023/2/16
Y1 - 2023/2/16
N2 - Introduction: Constraint-induced movement therapy (CIMT) and noninvasive brain stimulation (NIBS) are used to counteract learned nonuse phenomenon and imbalance in interhemispheric inhibition following stroke. The aim of this study is to summarize the available evidence on the effects of combining NIBS with CIMT in patients with stroke. Method: PubMed, Embase, Web of Science (WoS), PEDro, OTSeeker, and CENTRAL were searched for randomized controlled trials comparing the use of NIBS+CIMT with sham NIBS+CIMT. Data on variables such as time since stroke and mean scores and standard deviations on outcomes assessed such as motor function were extracted. Cochrane risks of bias assessment tool and PEDro scale were used to assess the risk of bias and methodological quality of the included studies. Results: The results showed that both NIBS+CIMT and sham NIBS+CIMT improved all outcomes post-intervention and at follow-up. However, NIBS+CIMT is superior to sham NIBS+CIMT at improving level of motor impairment (SMD = 1.75, 95% CI = 0.49 to 3.01, P = 0.007) post-intervention and hand function (SMD = 1.21, 95% CI = 0.07 to 2.35, P = 0.04) at follow-up. Conclusions: The addition of NIBS to CIMT seems to provide additional benefits to the recovery of function following stroke.
AB - Introduction: Constraint-induced movement therapy (CIMT) and noninvasive brain stimulation (NIBS) are used to counteract learned nonuse phenomenon and imbalance in interhemispheric inhibition following stroke. The aim of this study is to summarize the available evidence on the effects of combining NIBS with CIMT in patients with stroke. Method: PubMed, Embase, Web of Science (WoS), PEDro, OTSeeker, and CENTRAL were searched for randomized controlled trials comparing the use of NIBS+CIMT with sham NIBS+CIMT. Data on variables such as time since stroke and mean scores and standard deviations on outcomes assessed such as motor function were extracted. Cochrane risks of bias assessment tool and PEDro scale were used to assess the risk of bias and methodological quality of the included studies. Results: The results showed that both NIBS+CIMT and sham NIBS+CIMT improved all outcomes post-intervention and at follow-up. However, NIBS+CIMT is superior to sham NIBS+CIMT at improving level of motor impairment (SMD = 1.75, 95% CI = 0.49 to 3.01, P = 0.007) post-intervention and hand function (SMD = 1.21, 95% CI = 0.07 to 2.35, P = 0.04) at follow-up. Conclusions: The addition of NIBS to CIMT seems to provide additional benefits to the recovery of function following stroke.
KW - brain stimulation
KW - constraint-induced movement therapy
KW - interhemispheric inhibition
KW - learned nonuse
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85148451727&partnerID=8YFLogxK
U2 - 10.1080/14737175.2023.2177154
DO - 10.1080/14737175.2023.2177154
M3 - Journal article
C2 - 36745928
AN - SCOPUS:85148451727
SN - 1473-7175
VL - 23
SP - 187
EP - 203
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
IS - 2
ER -