TY - JOUR
T1 - Cobalt Single-Atom-Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity
AU - Chen, Zhongxin
AU - Liu, Cuibo
AU - Liu, Jia
AU - Li, Jing
AU - Xi, Shibo
AU - Chi, Xiao
AU - Xu, Haisen
AU - Park, In Hyeok
AU - Peng, Xinwen
AU - Li, Xing
AU - Yu, Wei
AU - Liu, Xiaowang
AU - Zhong, Linxin
AU - Leng, Kai
AU - Huang, Wei
AU - Koh, Ming Joo
AU - Loh, Kian Ping
N1 - Funding Information:
Z.C., C.L., and J.L. contributed equally to this work. K.P.L. thanks National Research Foundation, Singapore for NRF Investigator Award ?Graphene oxide a new class of catalytic, ionic and molecular sieving materials? (award number NRF-NRF12015-01). M.J.K. thanks the National University of Singapore start-up grant under the President's Assistant Professorship Scheme. The authors appreciate Poh Chong Lim, Dr. Ming Lin at A*STAR, IMRE, for GIXRD measurements, and Dr. Jiajia Zhang and Prof. Hongbin Lu at Fudan University for SAXS tests.
Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/1/28
Y1 - 2020/1/28
N2 - The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long-standing pursuit in chemical synthesis. A vertically structured, cobalt single atom-intercalated molybdenum disulfide catalyst (Co1-in-MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single-atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide-bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high-value, multifunctional sulfones and late-stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom-intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.
AB - The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long-standing pursuit in chemical synthesis. A vertically structured, cobalt single atom-intercalated molybdenum disulfide catalyst (Co1-in-MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single-atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide-bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high-value, multifunctional sulfones and late-stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom-intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.
KW - chemoselective transformation
KW - electrochemical intercalation
KW - organic catalysis
KW - single-atom materials
KW - transition metal dichalcogenides
UR - http://www.scopus.com/inward/record.url?scp=85075754561&partnerID=8YFLogxK
U2 - 10.1002/adma.201906437
DO - 10.1002/adma.201906437
M3 - Journal article
C2 - 31777990
AN - SCOPUS:85075754561
SN - 0935-9648
VL - 32
JO - Advanced Materials
JF - Advanced Materials
IS - 4
M1 - 1906437
ER -