TY - JOUR
T1 - Clothing Spiny Nanoprobes against the Mononuclear Phagocyte System Clearance in vivo: Photoacoustic Diagnosis and Photothermal Treatment of Early Stage Liver Cancer with Erythrocyte Membrane-Camouflaged Gold Nanostars
T2 - Photoacoustic diagnosis and photothermal treatment of early stage liver cancer with erythrocyte membrane-camouflaged gold nanostars
AU - Huang, Xiazi
AU - Shang, Wenting
AU - Deng, Han
AU - Zhou, Yingying
AU - Cao, Fei
AU - Fang, Chihua
AU - Tian, Jie
PY - 2020/3
Y1 - 2020/3
N2 - Nanoprobes have been increasingly applied in photoacoustic imaging to improve the diagnosis and treatment of diseases, especially the liver cancer, the fourth leading cause of cancer-related deaths worldwide. The mononuclear phagocytic system (MPS), however, exhibits a crucial impediment to the probe usage, preventing the accumulation of probes within the liver. This, in turn, paralyzes the effort of diagnosis enhancement. To overcome the MPS clearance, a biomimetic probe consisting of erythrocyte membrane-camouflaged gold nanostars was designed and synthesized in this study. The probe possesses broad absorption spectrum, photostability, and photothermal conversion efficiency. More importantly, it yields preeminent immune escape ability, thus being able to escape the MPS clearance and greatly boost the accumulation of probes at the tumor sites with prolonged blood circulation. Experimentally, we demonstrate that the probe can serve as an effective nanoprobe to enhance the in vivo photoacoustic imaging and photothermal treatment of in situ early stage liver tumors in mice.
AB - Nanoprobes have been increasingly applied in photoacoustic imaging to improve the diagnosis and treatment of diseases, especially the liver cancer, the fourth leading cause of cancer-related deaths worldwide. The mononuclear phagocytic system (MPS), however, exhibits a crucial impediment to the probe usage, preventing the accumulation of probes within the liver. This, in turn, paralyzes the effort of diagnosis enhancement. To overcome the MPS clearance, a biomimetic probe consisting of erythrocyte membrane-camouflaged gold nanostars was designed and synthesized in this study. The probe possesses broad absorption spectrum, photostability, and photothermal conversion efficiency. More importantly, it yields preeminent immune escape ability, thus being able to escape the MPS clearance and greatly boost the accumulation of probes at the tumor sites with prolonged blood circulation. Experimentally, we demonstrate that the probe can serve as an effective nanoprobe to enhance the in vivo photoacoustic imaging and photothermal treatment of in situ early stage liver tumors in mice.
KW - Biomimetic camouflage
KW - Liver cancer
KW - Mononuclear phagocytic system
KW - Nanoprobe
KW - Photoacoustic imaging
KW - Photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85075344907&partnerID=8YFLogxK
U2 - 10.1016/j.apmt.2019.100484
DO - 10.1016/j.apmt.2019.100484
M3 - Journal article
AN - SCOPUS:85075344907
SN - 2352-9407
VL - 18
JO - Applied Materials Today
JF - Applied Materials Today
M1 - 100484
ER -