Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese

K. H. Chan, K. L. Tsang, P. W.L. Ho, C. T. Tse, J. S.C. Kwan, J. W.M. Ho, A. C.Y. Chu, R. S.K. Chang, S. L. Ho

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)


Background: Clinical outcome of Chinese relapsing remitting multiple sclerosis (RRMS) patients is uncertain. Aim: To study the long-term clinical outcome of Chinese RRMS patients. Method: RRMS patients with duration of 10 years or longer followed up in our hospital is retrospectively studied. Results: 61 RRMS patients (75% female) were studied. Their mean symptom onset age was 25.9 years and mean duration was 20.6 years (range 10-33); 36% patients had received β-interferon and 30% azathioprine. Their mean EDSS scores were 3.3 (range 1-7) and 4.7 (range 1-8) at 10 years and latest follow-up (mean duration 20.6 years) respectively. At 10 years, 30% patients had EDSS score ≤2, 34% EDSS 2.5-3.5, 20% EDSS 4.0-5.5 and 16% ≥6; 18% developed SPMS. At latest follow-up, 15% patients had EDSS ≤2, 20% EDSS 2.5-3.5, 19% EDSS 4.0-5.5 and 46% ≥6.0; 53% developed SPMS. The median time from symptom onset to EDSS 6 was 22 years. No differences were detected in demographic characteristics, presenting neurological features, number of attacks in first 2 years, neuroradiological findings and disease modifying therapies between patients with EDSS <6 and ≥6 at ten years. EDSS scores at 10 years and latest follow-up were similar for patients who had received β-interferon and those who had not. Conclusion: Hong Kong Chinese RRMS patients may have worse long-term clinical outcome than Caucasian patients.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalClinical Neurology and Neurosurgery
Issue number8
Publication statusPublished - Oct 2011
Externally publishedYes


  • β-Interferon
  • Expanded disability status scale score
  • Hong Kong Chinese
  • Relapsing remitting multiple sclerosis
  • Secondary progression multiple sclerosis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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