Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye

Jiajia Chen, Qianying Gao, Yaqin Liu, Jian Ge, Xianwu Cao, Yan Luo, Danping Huang, Gege Zhou, Shaofen Lin, Jianxian Lin, Chi Ho To, Andrew W. Siu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

15 Citations (Scopus)

Abstract

We previously proposed a new strategy to replace a vitreous body with a novel foldable capsular vitreous body (FCVB). In this study, the FCVB was designed to mimic natural vitreous morphology, and evaluate its physiological functions compared with traditional silicone oil substitutes, in an established rabbit model of proliferative vitreoretinopathy. We found that FCVB was a very good replacement for closely mimicking the morphology and restoring the physiological functions, such as the support, refraction, and cellular barriers, of the rabbit vitreous body. The study has provided us with a novel research and therapy strategy that could effectively mimic the morphology and physiological function of the rabbit vitreous body.
Original languageEnglish
Pages (from-to)396-404
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume97 B
Issue number2
DOIs
Publication statusPublished - 1 May 2011

Keywords

  • device
  • PVR
  • rabbit
  • vitreous substitute

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this