Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye

Jiajia Chen; Qianying Gao; Yaqin Liu; Jian Ge; Xianwu Cao; Yan Luo; Danping Huang; Gege Zhou; Shaofen Lin; Jianxian Lin; Chi Ho To; Andrew W. Siu

doi:10.1002/jbm.b.31812

Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye

Jiajia Chen, Qianying Gao, Yaqin Liu, Jian Ge, Xianwu Cao, Yan Luo, Danping Huang, Gege Zhou, Shaofen Lin, Jianxian Lin, Chi Ho To, Andrew W. Siu

Research output: Journal article publication › Journal article › Academic research › peer-review

23 Citations (Scopus)

Abstract

We previously proposed a new strategy to replace a vitreous body with a novel foldable capsular vitreous body (FCVB). In this study, the FCVB was designed to mimic natural vitreous morphology, and evaluate its physiological functions compared with traditional silicone oil substitutes, in an established rabbit model of proliferative vitreoretinopathy. We found that FCVB was a very good replacement for closely mimicking the morphology and restoring the physiological functions, such as the support, refraction, and cellular barriers, of the rabbit vitreous body. The study has provided us with a novel research and therapy strategy that could effectively mimic the morphology and physiological function of the rabbit vitreous body.

Original language	English
Pages (from-to)	396-404
Number of pages	9
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	97 B
Issue number	2
DOIs	https://doi.org/10.1002/jbm.b.31812
Publication status	Published - 1 May 2011

Keywords

device
PVR
rabbit
vitreous substitute

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

More information

10.1002/jbm.b.31812

Cite this

Chen, J., Gao, Q., Liu, Y., Ge, J., Cao, X., Luo, Y., Huang, D., Zhou, G., Lin, S., Lin, J., To, C. H., & Siu, A. W. (2011). Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 97 B(2), 396-404. https://doi.org/10.1002/jbm.b.31812

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abstract = "We previously proposed a new strategy to replace a vitreous body with a novel foldable capsular vitreous body (FCVB). In this study, the FCVB was designed to mimic natural vitreous morphology, and evaluate its physiological functions compared with traditional silicone oil substitutes, in an established rabbit model of proliferative vitreoretinopathy. We found that FCVB was a very good replacement for closely mimicking the morphology and restoring the physiological functions, such as the support, refraction, and cellular barriers, of the rabbit vitreous body. The study has provided us with a novel research and therapy strategy that could effectively mimic the morphology and physiological function of the rabbit vitreous body.",

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author = "Jiajia Chen and Qianying Gao and Yaqin Liu and Jian Ge and Xianwu Cao and Yan Luo and Danping Huang and Gege Zhou and Shaofen Lin and Jianxian Lin and To, {Chi Ho} and Siu, {Andrew W.}",

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doi = "10.1002/jbm.b.31812",

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Chen, J, Gao, Q, Liu, Y, Ge, J, Cao, X, Luo, Y, Huang, D, Zhou, G, Lin, S, Lin, J, To, CH & Siu, AW 2011, 'Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye', Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 97 B, no. 2, pp. 396-404. https://doi.org/10.1002/jbm.b.31812

Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye. / Chen, Jiajia; Gao, Qianying; Liu, Yaqin et al.
In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 97 B, No. 2, 01.05.2011, p. 396-404.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Chen, Jiajia

AU - Gao, Qianying

AU - Liu, Yaqin

AU - Ge, Jian

AU - Cao, Xianwu

AU - Luo, Yan

AU - Huang, Danping

AU - Zhou, Gege

AU - Lin, Shaofen

AU - Lin, Jianxian

AU - To, Chi Ho

AU - Siu, Andrew W.

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KW - PVR

KW - rabbit

KW - vitreous substitute

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Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye

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Keywords

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