Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics

Tung Ting Sham; Meng Heng Li; Chi On Chan; Huan Zhang; Shun Wan Chan; Kam Wah Mok

doi:10.1016/j.jff.2016.11.011

Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics

Tung Ting Sham, Meng Heng Li, Chi On Chan, Huan Zhang, Shun Wan Chan, Kam Wah Mok

Research output: Journal article publication › Journal article › Academic research › peer-review

15 Citations (Scopus)

Abstract

Piceatannol supplement significantly lowered the total cholesterols, low density lipoprotein cholesterol levels and the atherogenic index as compared to the HFD model which only have increased dietary cholesterol intake. Using untargeted mass spectrometry-based metabolomic platforms, multivariate statistics revealed that HFD significantly perturbed fatty acids, lysophospholipids, bile acids and conjugated bile acids. Reduced CYP7A1 protein expression and increase in glycocholate and taurodeoxycholate after piceatannol treatment suggested the conjugated bile acid might contribute to the cholesterol-lowering effect. For lipid profiles, lysoPC (20:2) and lysoPC (20:0) were decreased while the ratio of esterified arachidonic acid to esterified dihomo-γ linoleic acid was up-regulated for rats after piceatannol supplement. These results indicated that the therapeutic effect of piceatannol is associated with bile acid and fatty acid metabolisms and reduced absorption of dietary cholesterols.

Original language	English
Pages (from-to)	127-137
Number of pages	11
Journal	Journal of Functional Foods
Volume	28
DOIs	https://doi.org/10.1016/j.jff.2016.11.011
Publication status	Published - 1 Jan 2017

Keywords

GC-MS.
Hyperlipidemia
Metabolomics
Piceatannol
Polyphenols
UPLC-MS

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

More information

10.1016/j.jff.2016.11.011

http://hdl.handle.net/10397/101593

Cite this

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title = "Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics",

abstract = "Piceatannol supplement significantly lowered the total cholesterols, low density lipoprotein cholesterol levels and the atherogenic index as compared to the HFD model which only have increased dietary cholesterol intake. Using untargeted mass spectrometry-based metabolomic platforms, multivariate statistics revealed that HFD significantly perturbed fatty acids, lysophospholipids, bile acids and conjugated bile acids. Reduced CYP7A1 protein expression and increase in glycocholate and taurodeoxycholate after piceatannol treatment suggested the conjugated bile acid might contribute to the cholesterol-lowering effect. For lipid profiles, lysoPC (20:2) and lysoPC (20:0) were decreased while the ratio of esterified arachidonic acid to esterified dihomo-γ linoleic acid was up-regulated for rats after piceatannol supplement. These results indicated that the therapeutic effect of piceatannol is associated with bile acid and fatty acid metabolisms and reduced absorption of dietary cholesterols.",

keywords = "GC-MS., Hyperlipidemia, Metabolomics, Piceatannol, Polyphenols, UPLC-MS",

author = "Sham, {Tung Ting} and Li, {Meng Heng} and Chan, {Chi On} and Huan Zhang and Chan, {Shun Wan} and Mok, {Kam Wah}",

year = "2017",

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doi = "10.1016/j.jff.2016.11.011",

language = "English",

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journal = "Journal of Functional Foods",

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TY - JOUR

T1 - Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics

AU - Sham, Tung Ting

AU - Li, Meng Heng

AU - Chan, Chi On

AU - Zhang, Huan

AU - Chan, Shun Wan

AU - Mok, Kam Wah

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Piceatannol supplement significantly lowered the total cholesterols, low density lipoprotein cholesterol levels and the atherogenic index as compared to the HFD model which only have increased dietary cholesterol intake. Using untargeted mass spectrometry-based metabolomic platforms, multivariate statistics revealed that HFD significantly perturbed fatty acids, lysophospholipids, bile acids and conjugated bile acids. Reduced CYP7A1 protein expression and increase in glycocholate and taurodeoxycholate after piceatannol treatment suggested the conjugated bile acid might contribute to the cholesterol-lowering effect. For lipid profiles, lysoPC (20:2) and lysoPC (20:0) were decreased while the ratio of esterified arachidonic acid to esterified dihomo-γ linoleic acid was up-regulated for rats after piceatannol supplement. These results indicated that the therapeutic effect of piceatannol is associated with bile acid and fatty acid metabolisms and reduced absorption of dietary cholesterols.

AB - Piceatannol supplement significantly lowered the total cholesterols, low density lipoprotein cholesterol levels and the atherogenic index as compared to the HFD model which only have increased dietary cholesterol intake. Using untargeted mass spectrometry-based metabolomic platforms, multivariate statistics revealed that HFD significantly perturbed fatty acids, lysophospholipids, bile acids and conjugated bile acids. Reduced CYP7A1 protein expression and increase in glycocholate and taurodeoxycholate after piceatannol treatment suggested the conjugated bile acid might contribute to the cholesterol-lowering effect. For lipid profiles, lysoPC (20:2) and lysoPC (20:0) were decreased while the ratio of esterified arachidonic acid to esterified dihomo-γ linoleic acid was up-regulated for rats after piceatannol supplement. These results indicated that the therapeutic effect of piceatannol is associated with bile acid and fatty acid metabolisms and reduced absorption of dietary cholesterols.

KW - GC-MS.

KW - Hyperlipidemia

KW - Metabolomics

KW - Piceatannol

KW - Polyphenols

KW - UPLC-MS

UR - http://www.scopus.com/inward/record.url?scp=84998678846&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2016.11.011

DO - 10.1016/j.jff.2016.11.011

M3 - Journal article

SN - 1756-4646

VL - 28

SP - 127

EP - 137

JO - Journal of Functional Foods

JF - Journal of Functional Foods

ER -

Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics

Abstract

Keywords

ASJC Scopus subject areas

More information

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