Chitosan microcapsules loaded with either miconazole nitrate or clotrimazole, prepared via emulsion technique

Chun Wah Marcus Yuen, Yiu Wan Yip, Liwei Liu, Kevin Cheuk, Chi Wai Kan, Hing Cheong Cheung, Shuk Yan Cheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

36 Citations (Scopus)


In this paper, a simple and versatile coacervation technique has been developed by using an ultrasound-assisted oil/water emulsion method for the preparation of antifungal agent-loaded microcapsules. Two types of chitosan microcapsules are successfully prepared. The mean particle size of the chitosan/miconazole nitrate microcapsules is 2.6 μm and that of the chitosan/clotrimazole microcapsules is 4.1 μm. The encapsulation efficiency of the chitosan/miconazole nitrate microcapsules (77.58-96.81%) is relatively higher than that of the chitosan/clotrimazole microcapsules (56.66-93.82%). The in vitro drug release performance of the microcapsules shows that the chitosan/miconazole nitrate microcapsules release about 49.5% of the drug while chitosan/clotrimazole microcapsules release more than 66.1% of the drug after 12 h under a pressure of 5 kg at pH 5.5, which is similar to the pH of human skin. The prepared drug-loaded microcapsules could be applied onto bandages or socks, and will continuously release antifungal drugs in a controlled manner under pressure.
Original languageEnglish
Pages (from-to)795-801
Number of pages7
JournalCarbohydrate Polymers
Issue number3
Publication statusPublished - 1 Jul 2012


  • Chitosan
  • Clotrimazole
  • Control-release
  • Miconazole
  • Microcapsules

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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