Abstract
A series of pyrrolidine derivatives with β-amino alcohol moieties prepared from (S)-proline were found to catalyze the enantioselective addition of diethylzinc to aldehydes to yield optically active secondary alcohols with high enantioselectivities. A mechanism accounting for the configurational change with the bulkiness of chiral ligands is proposed.
Original language | English |
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Pages (from-to) | 133-138 |
Number of pages | 6 |
Journal | Tetrahedron Asymmetry |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 15 Jan 1999 |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry