Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes

Xiaowu Yang, Jianheng Shen, Chaoshan Da, Rui Wang, Michael C.K. Choi, Liwei Yang, Kwok Yin Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

58 Citations (Scopus)


A series of pyrrolidine derivatives with β-amino alcohol moieties prepared from (S)-proline were found to catalyze the enantioselective addition of diethylzinc to aldehydes to yield optically active secondary alcohols with high enantioselectivities. A mechanism accounting for the configurational change with the bulkiness of chiral ligands is proposed.
Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalTetrahedron Asymmetry
Issue number1
Publication statusPublished - 15 Jan 1999

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this