Chiral Cyclometalated Oxazoline Gold(III) Complex-Catalyzed Asymmetric Carboalkoxylation of Alkynes

Jia Jun Jiang, Jian Fang Cui, Bin Yang, Yulu Ning, Nathanael Chun Him Lai, Man Kin Wong (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)

Abstract

Asymmetric catalysis by using novel chiral O,O′-chelated 4,4′-biphenol cyclometalated oxazoline gold(III) complexes has been developed. A high yield (≤89%) and a high enantioselectivity (≤90% ee) were achieved in asymmetric carboalkoxylation of alkynes. Enantioselectivity could be significantly improved from 19% to 90% ee by increasing the steric size of the substituent on the chiral oxazoline ligand. Catalytically active AuIII species and the origin of chiral induction are proposed.

Original languageEnglish
Pages (from-to)6289-6294
Number of pages6
JournalOrganic Letters
Volume21
Issue number16
DOIs
Publication statusPublished - 16 Aug 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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