CHIRAL CYCLEN COMPOUNDS AND THEIR USES

Ga Lai Law; Lixiong Dai

CHIRAL CYCLEN COMPOUNDS AND THEIR USES

Ga Lai Law (Inventor)
, Lixiong Dai (Inventor)

Research output: Patents, agreements, assignments and companies › Patents granted

Abstract

The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.

Original language	English
Patent number	11,357,873
Priority date	19/09/16
Filing date	23/06/17
Publication status	Published - 14 Jun 2022

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title = "CHIRAL CYCLEN COMPOUNDS AND THEIR USES",

abstract = "The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.",

author = "Law, \{Ga Lai\} and Lixiong Dai",

year = "2022",

month = jun,

day = "14",

language = "English",

type = "Patent",

note = "11,357,873",

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TY - PAT

T1 - CHIRAL CYCLEN COMPOUNDS AND THEIR USES

AU - Law, Ga Lai

AU - Dai, Lixiong

PY - 2022/6/14

Y1 - 2022/6/14

N2 - The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.

AB - The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.

M3 - Patents granted

M1 - 11,357,873

Y2 - 2017/06/23

ER -

CHIRAL CYCLEN COMPOUNDS AND THEIR USES

Abstract

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