CHIRAL CYCLEN COMPOUNDS AND THEIR USES

Ga Lai Law (Inventor), Lixiong Dai (Inventor)

Research output: Patents, agreements, assignments and companiesPatents granted

Abstract

The present invention relates to the preparation of a series of chiral DOTA, DO3A, DO2A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA-based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.
Original languageEnglish
Patent number11,357,873
Priority date19/09/16
Filing date23/06/17
Publication statusPublished - 14 Jun 2022

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