Chiral acetylenic sulfoxide in organic synthesis: Addition of chiral secondary amines

Sujun Yan, K. T. Lam, K. T. Mo, Wai Yeung Wong, W. H. Chan, Albert W.M. Lee

Research output: Journal article publicationReview articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Chiral secondary amines of the 3,4-dimethoxyphenylethyl and the tryptamine system were reacted with chiral acetylenic sulfoxides and achiral acetylenic sulfone. In the case of 3,4 -dimethoxyphenylethyl amine, much improved diastereoselectivity (96 : 4) was observed as compared to the reaction of achiral secondary amine with chiral acetylenic sulfoxides.
Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalLetters in Organic Chemistry
Volume2
Issue number1
DOIs
Publication statusPublished - 1 Feb 2005
Externally publishedYes

Keywords

  • Alkaloid synthesis
  • Asymmetric synthesis
  • Chiral sulfoxide
  • Diastereoselectivity

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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