Chemical vapor deposition grown graphene DNA field-effect transistor biosensor with gold nanoparticles signal amplification

Chun Yu Chan, Feng Yan, Mo Yang

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

3 Citations (Scopus)

Abstract

This paper presents a graphene-based bio-field-effect transistor (bioFET) for the detection of avian influenza A virus subtype H7 gene. This bioFET was realized by directly assembling capture probes on graphene surface via n-n stacking interaction. The extended long capture probes is a simple and stable biofunctionalization strategy. Reporter probes conjugated to AuNPs were then applied to hybridize with H7 target in a sandwich assay format for signal amplification. Transfer curves were recorded to demonstrate the improved analytical performance with AuNPs-reporter probes signal amplification. This bioFET biosensor exhibited lower limit of detect (LOD) of 64 fM, which is yet the lowest among other graphene-based bioFET for DNA detection.
Original languageEnglish
Title of host publicationMEMS 2016 - 29th IEEE International Conference on Micro Electro Mechanical Systems
PublisherIEEE
Pages290-293
Number of pages4
Volume2016-February
ISBN (Electronic)9781509019731
DOIs
Publication statusPublished - 26 Feb 2016
Event29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016 - Shanghai, China
Duration: 24 Jan 201628 Jan 2016

Conference

Conference29th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2016
Country/TerritoryChina
CityShanghai
Period24/01/1628/01/16

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

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