Chemical synthesis and biological study of 4β-carboxymethyl- epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortunei

Man Chun Law; Ka Chun Wong; Wai Yin Pang; Man Sau Wong; Tak Hang Chan

doi:10.1039/c2md20082a

Chemical synthesis and biological study of 4β-carboxymethyl- epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortunei

Man Chun Law
, Ka Chun Wong
, Wai Yin Pang
, Man Sau Wong
, Tak Hang Chan

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

2 Citations (Scopus)

Abstract

The chemically synthesized active osteoprotective component 12 of Drynaria fortunei (kunze) J. Sm showed potent proliferative activity on UMR-106 osteoblast-like cells and selectively activate ERE-dependent gene transcription mediated by ERα but not ERβ.

Original language	English
Pages (from-to)	801-806
Number of pages	6
Journal	MedChemComm
Volume	3
Issue number	7
DOIs	https://doi.org/10.1039/c2md20082a
Publication status	Published - 1 Jul 2012

ASJC Scopus subject areas

Biochemistry
Pharmaceutical Science

More information

10.1039/c2md20082a

http://hdl.handle.net/10397/89615

Cite this

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title = "Chemical synthesis and biological study of 4β-carboxymethyl- epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortunei",

abstract = "The chemically synthesized active osteoprotective component 12 of Drynaria fortunei (kunze) J. Sm showed potent proliferative activity on UMR-106 osteoblast-like cells and selectively activate ERE-dependent gene transcription mediated by ERα but not ERβ.",

author = "Law, \{Man Chun\} and Wong, \{Ka Chun\} and Pang, \{Wai Yin\} and Wong, \{Man Sau\} and Chan, \{Tak Hang\}",

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AU - Law, Man Chun

AU - Wong, Ka Chun

AU - Pang, Wai Yin

AU - Wong, Man Sau

AU - Chan, Tak Hang

PY - 2012/7/1

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N2 - The chemically synthesized active osteoprotective component 12 of Drynaria fortunei (kunze) J. Sm showed potent proliferative activity on UMR-106 osteoblast-like cells and selectively activate ERE-dependent gene transcription mediated by ERα but not ERβ.

AB - The chemically synthesized active osteoprotective component 12 of Drynaria fortunei (kunze) J. Sm showed potent proliferative activity on UMR-106 osteoblast-like cells and selectively activate ERE-dependent gene transcription mediated by ERα but not ERβ.

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U2 - 10.1039/c2md20082a

DO - 10.1039/c2md20082a

M3 - Journal article

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JF - MedChemComm

IS - 7

ER -

Chemical synthesis and biological study of 4β-carboxymethyl- epiafzelechin acid, an osteoprotective compound from the rhizomes of Drynaria fortunei

Abstract

ASJC Scopus subject areas

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