Chelator-free synthesis of a dual-modality PET/MRI agent

Feng Chen; Paul A. Ellison; Christina M. Lewis; Hao Hong; Yin Zhang; Sixiang Shi; Reinier Hernandez; M. Elizabeth Meyerand; Todd E. Barnhart; Weibo Cai

doi:10.1002/anie.201306306

Chelator-free synthesis of a dual-modality PET/MRI agent

Feng Chen, Paul A. Ellison, Christina M. Lewis, Hao Hong, Yin Zhang, Sixiang Shi, Reinier Hernandez, M. Elizabeth Meyerand, Todd E. Barnhart, Weibo Cai

Research output: Journal article publication › Journal article › Academic research › peer-review

108 Citations (Scopus)

Abstract

Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*As^III and *As ^V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.

Original language	English
Pages (from-to)	13319-13323
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	50
Early online date	24 Oct 2013
DOIs	https://doi.org/10.1002/anie.201306306
Publication status	Published - 9 Dec 2013
Externally published	Yes

Keywords

arsenic
cancer
magnetic resonance imaging
positron emission tomography
radiochemistry

ASJC Scopus subject areas

Catalysis
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201306306

Cite this

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title = "Chelator-free synthesis of a dual-modality PET/MRI agent",

abstract = "Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.",

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AU - Chen, Feng

AU - Ellison, Paul A.

AU - Lewis, Christina M.

AU - Hong, Hao

AU - Zhang, Yin

AU - Shi, Sixiang

AU - Hernandez, Reinier

AU - Meyerand, M. Elizabeth

AU - Barnhart, Todd E.

AU - Cai, Weibo

PY - 2013/12/9

Y1 - 2013/12/9

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AB - Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.

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KW - cancer

KW - magnetic resonance imaging

KW - positron emission tomography

KW - radiochemistry

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ER -

Chelator-free synthesis of a dual-modality PET/MRI agent

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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