Chelator-free synthesis of a dual-modality PET/MRI agent

Feng Chen, Paul A. Ellison, Christina M. Lewis, Hao Hong, Yin Zhang, Sixiang Shi, Reinier Hernandez, M. Elizabeth Meyerand, Todd E. Barnhart, Weibo Cai

Research output: Journal article publicationJournal articleAcademic researchpeer-review

90 Citations (Scopus)

Abstract

Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *As V,*=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in*As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy.

Original languageEnglish
Pages (from-to)13319-13323
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number50
Early online date24 Oct 2013
DOIs
Publication statusPublished - 9 Dec 2013
Externally publishedYes

Keywords

  • arsenic
  • cancer
  • magnetic resonance imaging
  • positron emission tomography
  • radiochemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this