Characterization of the colorectal cancer in a rabbit model using quantitative high-frequency endoscopic ultrasound

Cheng Liu, Yaoheng Yang, Lei Sun, Chih Chung Huang

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)


Colorectal cancer (CRC) at early stage often has no symptoms, which causes delay of successful treatments. Colonoscopy is clinically performed for screening, during which biopsy may be conducted; however, it is difficult to determine early stage CRC by ordinary endoscopy even with dye due to the insufficient superficial scope of colorectal surface for pre-cancerous diagnosis. Endoscopic ultrasound (EUS) has been widely used to visualize overall depth-view five-layered structural alteration of colorectal tract. The field of knowledge of high-frequency EUS with quantitative ultrasound (QUS) for early colorectal cancer diagnosis is yet to be fully determined and a reproducible and feasible animal model is appropriate for further development of this novel modality. VX2 CRC Rabbit model is first time used as a model for endoscopic ultrasound imaging according to our knowledge. In this study, we for the first time show the application of high-frequency EUS along with QUS to characterize malignant colorectal tumor and benign colorectal tissue in a rabbit model of VX2 colorectal cancer.
Original languageEnglish
Title of host publication2013 IEEE International Ultrasonics Symposium, IUS 2013
Number of pages4
Publication statusPublished - 1 Dec 2013
Event2013 IEEE International Ultrasonics Symposium, IUS 2013 - Prague, Czech Republic
Duration: 21 Jul 201325 Jul 2013


Conference2013 IEEE International Ultrasonics Symposium, IUS 2013
Country/TerritoryCzech Republic


  • Colorectal cancer (CRC)
  • Endoscopic ultrasound (EUS)
  • High-frequency
  • Quantitative ultrasound (QUS) characterization
  • Rabbit colorectal cancer model

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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