Characteristics and risk factors of bilateral nonarteritic anterior ischemic optic neuropathy

Lei Wang, Hou Bin Huang, Wei Wang, Shao Ying Tan, Shi Hui Wei

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)


Objective: To compare the clinical characteristics and risk factors of unilateral and bilateral onset in non-arteritic anterior ischemic optic neuropathy (NAION) patients. Design: Retrospective case series. Participants: A total of 201 patients of NAION were recruited in Department of Ophthalmology of PLA General Hospital from October 2009 to March 2015. Methods: Differences in clinical characteristics, including disease history, laboratory tests, carotid artery ultrasound, brain magnetic resonance imaging (MRI), polysomnography (PSG) and ambulatory blood pressure monitoring (ABPM), between groups were analyzed using Chi-square test or t-test. Main Outcome Measures: Age, gender, systemic disease, medications taken and anatomy of optic disc. Results: Among the 201 NAION patients, 67 patients were bilateral onset (6 of them happened bilaterally simultaneously or with an internal less than 1 week between the two eyes) and the other 134 patients were unilateral onset. There was no difference found between the two groups in age (54.69±10.43 vs 54.47±9.90 years old, P=0.988) and gender (Male: Female: 1.34:1 vs 2.05:1, P=0.22). Compare to the unilateral group, the bilateral group showed a higher percentage of hypertension (52.2% vs 37.3%, P=0.04), lower percentage of noctural hypotension (19.2% vs 37.2%, P=0.026), more frequent using of hypotensors (65.7% vs 40.3%, P=0.03), more frequent coexisting with obstructive sleep apnea syndrome (OSAHS) (35.4% vs 21.2%, P=0.036), and more frequent of obesity(17.9% vs 9.7%, P=0.031). There were no significant differences in smoking and drinking status, diabetes, dyslipidemia, carotid atherosclerosis, cerebral infarction, homocysteine serum cystine, crowded disc, or precipitating factor. Conclusions: Hypertension, hypotensive medications, obesity and coexist with OSAHS may be risk factors for the development of bilateral NAION.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalOphthalmology in China
Issue number6
Publication statusPublished - 25 Nov 2016
Externally publishedYes


  • Ischemic optic neuropathy
  • Risk factors

ASJC Scopus subject areas

  • Ophthalmology


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