Changes in bone density and geometry of the radius in chronic stroke and related factors: A one-year prospective study

Marco Yiu Chung Pang, Ming Zhang, L. S W Li, A. Y M Jones

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)


Objectives: To describe the changes in bone density and geometry of the radius after chronic stroke and the associated clinical factors. Methods: Twenty stroke patients (12 men and 8 women, age=42-78 years, time post-stroke=12-166 months) and 23 control participants (14 men and 9 women, age=53-77 years) were assessed at the time of enrolment and one year later. Peripheral quantitative computed tomography was used to scan the radius epiphysis (4% site) and diaphysis (33% site). Grip strength, spasticity, paretic arm disuse, physical activity, and vascular health were also evaluated. Results: During the follow-up period, only the cortical thickness and cortical bone mineral content (BMC) in the paretic radius diaphysis showed a decline that exceeded the least significant change value (p=0.002). Paretic arm disuse, lower vascular elasticity and physical activity level at initial assessment were significantly related to more decline in cortical thickness at this site (p<0.01). Conclusions: The paretic radius diaphysis sustained significant reduction in cortical thickness and cortical BMC over time in chronic stroke, but these changes were less pronounced than those previously reported in sub-acute stroke. Strategies to modify vascular health, disuse, and physical activity may be important in improving upper limb bone health but will need further investigations.
Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalJournal of Musculoskeletal Neuronal Interactions
Issue number1
Publication statusPublished - 1 Mar 2013


  • Cerebrovascular Accident
  • Muscle
  • Osteoporosis
  • Peripheral Quantitative Computed Tomography
  • Rehabilitation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Physiology


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