Cerebral autoregulation in response to posture change in elderly subjects-assessment by wavelet phase coherence analysis of cerebral tissue oxyhemoglobin concentrations and arterial blood pressure signals

Yuanjin Gao, Ming Zhang, Qingyu Han, Wenhao Li, Qing Xin, Yan Wang, Zengyong Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)

Abstract

This study aims to assess the dynamic cerebral autoregulation (dCA) in response to posture change using wavelet phase coherence (WPCO) of cerebral tissue oxyhemoglobin concentrations (Delta [HbO2]) and arterial blood pressure (ABP) signals in healthy elderly subjects. Continuous recordings of near-infrared spectroscopy (NIRS) and ABP signals were obtained from simultaneous measurements in 16 healthy elderly subjects (age: 68.9±7.1 years) and 19 young subjects (age: 24.9±3.2 years). The phase coherence between Delta [HbO2] and ABP oscillations in six frequency intervals (I, 0.6-2Hz; II, 0.15-0.6Hz; III, 0.05-0.15Hz; IV, 0.02-0.05Hz, V, 0.0095-0.02Hz and VI, 0.005-0.0095Hz) was analyzed using WPCO. The sit-to-stand posture change induces significantly lower WPCO in interval III (F=5.50 p=0.025) in the elderly subjects than in the young subjects. However, the stand-to-sit posture change induces higher WPCO in intervals II (F=5.25 p=0.028) and V (F=6.22 p=0.018) in the elderly subjects than in the young subjects. The difference of WPCO in response to posture change between the elderly and the young subjects indicates an altered CA due to aging. This study provides new insight into the dynamics of CA and may be useful in identifying the risk for dCA processes.
Original languageEnglish
Pages (from-to)330-336
Number of pages7
JournalBehavioural Brain Research
Volume278
DOIs
Publication statusPublished - 1 Feb 2015

Keywords

  • Aging
  • Cerebral tissue oxygenation
  • Near-infrared spectroscopy
  • Spontaneous oscillations
  • Wavelet phase coherence

ASJC Scopus subject areas

  • Behavioral Neuroscience

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