Cell compressibility studies utilizing noncontact hydrostatic pressure measurements on single living cells in a microchamber

L. A.G. Lin, A. Q. Liu, Y. F. Yu, C. Zhang, C. S. Lim, S. H. Ng, P. H. Yap, H. J. Gao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)

Abstract

A micro-optical-fluidic system (MOFS), which integrates a force generating device and an optical detector, is designed to measure the bulk modulus of a single living cell in real time under a controlled hydrostatic pressure. In this design, the accuracy of the bulk modulus measurement is improved because neither the force generating device nor the optical detector needs to be in contact with the cells. The MOFS device has been used to investigate the mechanotransduction of THP-1 human acute monocytic leukemia cells and the effects of the toxin lipopolysaccharide and colchicine on various properties of these cells.

Original languageEnglish
Article number233901
JournalApplied Physics Letters
Volume92
Issue number23
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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