Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression

Yue Li, Wui Man Lau, Kwok Fai So, Yao Tong, Jiangang Shen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)


In the present study, we aim to elucidate the role of caveolin-1 (Cav-1) in modulating oligodendroglial differentiation of neural progenitor cells (NPCs) in vivo and in vitro. For in vivo experiments, we investigated oligodendroglial differentiation by detecting the expressions of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) and β-catenin in the brains of wild type mice and Cav-1 knockout mice. Cav-1 knockout mice revealed more oligodendroglial differentiation, but lower levels of β-catenin expression than wild type mice. For in vitro experiments, we observed the potential roles of Cav-1 in modulating β-catenin expression and oligodendroglial differentiation in isolated cultured NPCs by manipulating Cav-1 expression with Cav-1 scaffolding domain peptide and Cav-1 RNA silencing approach. In the differentiating NPCs, Cav-1 scaffolding domain peptide markedly inhibited oligodendroglial formation, but up-regulated the expression of β-catenin. In contrast, the knockdown of Cav-1 promoted oligodendroglial differentiation of NPCs, but down-regulated the expression of β-catenin. Taken together, these results directly prove that caveolin-1 can inhibit oligodendroglial differentiation of NPCs through modulating β-catenin expression.
Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalNeurochemistry International
Issue number2
Publication statusPublished - 1 Aug 2011
Externally publishedYes


  • β-Catenin
  • Caveolin-1
  • Neural progenitor cells
  • Oligodendrocytes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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