Abstract
Pin the amine on the gamma: A new method has been developed for the γ-addition of nitrogen nucleophiles to γ-substituted alkynoates or allenoates through intra- and intermolecular processes that are catalyzed by spirophosphine 1 (see scheme). An asymmetric version of this reaction affords enantioenriched pyrrolidines, indolines, and γ-amino-α,β- unsaturated carbonyl compounds.
Original language | English |
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Pages (from-to) | 2525-2528 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 9 |
DOIs | |
Publication status | Published - 25 Feb 2013 |
Externally published | Yes |
Keywords
- amination
- asymmetric catalysis
- heterocycles
- organocatalysis
- phosphanes
ASJC Scopus subject areas
- Catalysis
- General Chemistry