Catalytic asymmetric addition reactions leading to carbon-carbon bond formation: Phenyl and alkenyl transfer to aldehydes and alkynylation of α-imino esters

Jian Xin Ji, Jing Wu, Lijin Xu, Chiu Wing Yip, Kim Hung Lam, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)

Abstract

Optically active tertiary aminonaphthol ligands were obtained by a new, convenient procedure and were found to catalyze the enantioselective alkenyl and phenyl transfer to aldehydes in high yields and excellent enantiomeric excesses (ee's). The catalytic asymmetric introduction of alkynyl functionality to α-amino acid derivatives was realized by the direct addition of terminal alkynes to α-imino ester in the presence of chiral copper(I) complex under mild reaction conditions.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalPure and Applied Chemistry
Volume78
Issue number2
DOIs
Publication statusPublished - 1 Feb 2006

Keywords

  • Alkenylation
  • Alkynylation
  • Asymmetric
  • Catalyst
  • Phenylation

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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