Case report: The occurrence of fibrillary lines in overnight orthokeratology

Sin Wan Cheung, Hie Hua Wong, Anthony J. Bron, Vincent Chui, Ben Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)


Background: To report the occurrence of concentric fibrillary lines in the central corneas of a 13-year-old girl during overnight orthokeratology. Methods: Observational case report. Results: The initial refractive errors and keratometric readings (flattest/steepest meridians) of the patient were -6.00/-0.50 × 180 and 45.25/46.20 D, respectively, in the right eye and -5.50 DS and 44.90/45.80 D, respectively in the left eye. She underwent orthokeratology for myopic control, with a target reduction of 4.00 D myopia. A pair of DreimLens lenses was prescribed to be worn on a nightly basis and spectacles were worn by day. The same orthokeratology lenses were used throughout the monitoring period. Corneal topography showed well-centred treatment zones but persistent peripheral corneal staining due to trichiasis. A faint, peripheral pigmented brownish corneal arc and bundles of fine concentric fibrillary lines were observed in the central cornea about 12 months after commencing lens wear. In view of the persistent corneal staining due to trichiasis, she was advised to stop the orthokeratology treatment after 16 months of lens wear and was prescribed 1-Day Acuvue® daily disposable contact lenses. The pigmented line disappeared after 2 months of hydrogel lens wear, while the fibrillary lines took 10 months to resolve. Conclusions: Fibrillary lines are a feature of the normal cornea thought to represent the arrangement of the subbasal, epithelial nerve plexus. We hypothesize that orthokeratology lens wear stimulates an altered epithelial migration pattern and a structural reorganisation of the subbasal nerve plexus in relation to this. This is assumed to account for the concentric pattern of fibrillary lines seen in our patient. The lines had no effect on vision and resolved over a period of 10 months following cessation of orthokeratology lens wear.
Original languageEnglish
Pages (from-to)525-531
Number of pages7
JournalOphthalmic and Physiological Optics
Issue number5
Publication statusPublished - 1 Sept 2006


  • Cornea
  • Fibrillary lines
  • Fleischer ring
  • Orthokeratology
  • Pigmented arc
  • Subbasal nerve plexus

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Sensory Systems


Dive into the research topics of 'Case report: The occurrence of fibrillary lines in overnight orthokeratology'. Together they form a unique fingerprint.

Cite this