Case report: Postradiation chondrosarcoma with a short latency period of 6 months

Sen Yang, Wei Tang, Xiu Fa Tang, Ming Xuan, Li Juan Guo, Xiao Yi Wang, Wings T.Y. Loo, Qing Liu, Louis W.C. Chow, Mary N.B. Cheung, Wai Nam Tsang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

We describe a case of postradiation chondrosarcoma after basal cell carcinoma treatment. At the time he presented, the patient was a 35-year-old man who had received radiotherapy at a dose of 70 Gy for 8 weeks. Six months after radiation treatment, a rapidly growing mass at the upper right alveolar ridge of the gums, where radiation had been given, was diagnosed as chondrosarcoma. Generally, chondrosarcoma occurs after a latency period of several years following radiation. However, there are a few relevant reports indicating that maxillofacial chondrosarcoma can develop after radiotherapy for basal cell carcinoma, with a short latency of 6 months. We hypothesize that the dosage and treatment time of radiation may have played a role in the opening/closing of the Hh-signaling pathway in the case of this patient.
Original languageEnglish
Pages (from-to)e440-e444
JournalInternational Journal of Biological Markers
Volume29
Issue number4
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • Basal cell carcinoma
  • Computed tomography
  • Maxillofacial chondrosarcoma
  • Postradiation chondrosarcoma
  • Radiotherapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Clinical Biochemistry
  • Cancer Research

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