Cascaded chemical sensing using a single cell as a sensor

Mo Yang, Shalini Prasad, Xuan Zhang, Mihrimah Ozkan, Cengiz S. Ozkan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

Cell based biosensors are portable devices containing living biological cells that monitor physiological changes induced by exposure to environmental perturbations from toxicants, pathogens or pollutants. Conventional sensing techniques lack the ability to detect a large number of known and unknown chemical agents, to characterize their functionality and to predict the resulting effects on human physiology. Here, we describe a sensing technique based on the development of single cell arrays with the ability to detect a broad spectrum of chemical agents based on the modification of extracellular electrical activity. The complex modulated signal spectrum is analyzed via Fourier and wavelet transformation techniques to yield unique identifiers called "Signature Patterns".
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalSensor Letters
Volume2
Issue number1
DOIs
Publication statusPublished - 1 Mar 2004
Externally publishedYes

Keywords

  • Cascaded sensing
  • Dielectrophoretic trap
  • Eigen vector
  • Osteoblast
  • Signal modulation
  • Signature pattern
  • Single cell sensor

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

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