@article{12c1357a43ea4f7ca9653380fa7b22ff,
title = "Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis",
abstract = "The superlubrication of natural joint has been attributed to hydration lubrication of articular cartilage. Here, inspired by the structure of phosphatidylcholine lipid (a typical cartilage matrix) with the presence of zwitterionic charges, we developed superlubricated nanospheres, namely poly (2-methacryloyloxyethyl phosphorylcholine)-grafted mesoporous silica nanospheres (MSNs-NH2@PMPC), via photopolymerization. The biomimetic nanospheres could enhance lubrication due to the formation of a tenacious hydration layer surrounding the zwitterionic charges of polymer brushes (PMPC), and achieve local delivery of an anti-inflammatory drug employing the nanocarriers (MSNs). The tribological and drug release tests showed improved lubrication and sustained drug release of the nanospheres. Additionally, the in vitro and in vivo tests revealed that the superlubricated drug-loaded nanospheres inhibited the development of osteoarthritis by up-regulating cartilage anabolic components and down-regulating catabolic proteases and pain-related gene. The nanospheres, with an integrated feature of both enhanced lubrication and sustained drug delivery, can be an efficient intra-articular nanomedicine for the treatment of osteoarthritis.",
keywords = "Articular cartilage, Biomimetic, Hydration lubrication, Nanospheres, Osteoarthritis",
author = "Hao Chen and Tao Sun and Yufei Yan and Xiuling Ji and Yulong Sun and Xin Zhao and Jin Qi and Wenguo Cui and Lianfu Deng and Hongyu Zhang",
note = "Funding Information: This study was financially supported by National Natural Science Foundation of China ( 51675296 , 81972134 , 81702125 ), Tsinghua University Initiative Scientific Research Program ( 20197050026 ), Tsinghua University- Peking Union Medical College Hospital Initiative Scientific Research Program ( 20191080593 ), Shanghai Municipal Education Commission —Gaofeng Clinical Medicine Grant Support ( 20171906 ), Shanghai Jiao Tong University “Medical and Research” Program ( ZH2018ZDA04 ), Science and Technology Commission of Shanghai Municipality ( 18ZR1434200 , 19440760400 ), and Ng Teng Fong Charitable Foundation ( 202-276-132-13 ). Funding Information: This study was financially supported by National Natural Science Foundation of China (51675296, 81972134, 81702125), Tsinghua University Initiative Scientific Research Program (20197050026), Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program (20191080593), Shanghai Municipal Education Commission?Gaofeng Clinical Medicine Grant Support (20171906), Shanghai Jiao Tong University ?Medical and Research? Program (ZH2018ZDA04), Science and Technology Commission of Shanghai Municipality (18ZR1434200, 19440760400), and Ng Teng Fong Charitable Foundation (202-276-132-13). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = jun,
doi = "10.1016/j.biomaterials.2020.119931",
language = "English",
volume = "242",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier Ltd",
}