CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus

Jia-chi Chiou; Ruichao Li; Sheng Chen

doi:10.1128/AAC.00047-15

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus

Jia-chi Chiou, Ruichao Li, Sheng Chen

Research output: Journal article publication › Journal article › Academic research › peer-review

60 Citations (Scopus)

Abstract

Vibrio parahaemolyticus is commonly resistant to ampicillin, yet the mechanisms underlying this phenomenon are not clear. In this study, a novel class A carbenicillin-hydrolyzing β-lactamase (CARB) family of β-lactamases, blaCARB-17, was identified and found to be responsible for the intrinsic penicillin resistance in V. parahaemolyticus. Importantly, blaCARB-17-like genes were present in all 293 V. parahaemolyticus genome sequences available in GenBank and detectable in all 91 V. parahaemolyticus food isolates, further confirming the intrinsic nature of this gene.

Original language	English
Pages (from-to)	3593-3595
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00047-15
Publication status	Published - 1 Jan 2015

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1128/AAC.00047-15

Cite this

@article{6c9093e0bd754d5c83ab6df8e137d743,

title = "CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus",

abstract = "Vibrio parahaemolyticus is commonly resistant to ampicillin, yet the mechanisms underlying this phenomenon are not clear. In this study, a novel class A carbenicillin-hydrolyzing β-lactamase (CARB) family of β-lactamases, blaCARB-17, was identified and found to be responsible for the intrinsic penicillin resistance in V. parahaemolyticus. Importantly, blaCARB-17-like genes were present in all 293 V. parahaemolyticus genome sequences available in GenBank and detectable in all 91 V. parahaemolyticus food isolates, further confirming the intrinsic nature of this gene.",

author = "Jia-chi Chiou and Ruichao Li and Sheng Chen",

year = "2015",

month = jan,

day = "1",

doi = "10.1128/AAC.00047-15",

language = "English",

volume = "59",

pages = "3593--3595",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "6",

}

TY - JOUR

T1 - CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus

AU - Chiou, Jia-chi

AU - Li, Ruichao

AU - Chen, Sheng

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Vibrio parahaemolyticus is commonly resistant to ampicillin, yet the mechanisms underlying this phenomenon are not clear. In this study, a novel class A carbenicillin-hydrolyzing β-lactamase (CARB) family of β-lactamases, blaCARB-17, was identified and found to be responsible for the intrinsic penicillin resistance in V. parahaemolyticus. Importantly, blaCARB-17-like genes were present in all 293 V. parahaemolyticus genome sequences available in GenBank and detectable in all 91 V. parahaemolyticus food isolates, further confirming the intrinsic nature of this gene.

AB - Vibrio parahaemolyticus is commonly resistant to ampicillin, yet the mechanisms underlying this phenomenon are not clear. In this study, a novel class A carbenicillin-hydrolyzing β-lactamase (CARB) family of β-lactamases, blaCARB-17, was identified and found to be responsible for the intrinsic penicillin resistance in V. parahaemolyticus. Importantly, blaCARB-17-like genes were present in all 293 V. parahaemolyticus genome sequences available in GenBank and detectable in all 91 V. parahaemolyticus food isolates, further confirming the intrinsic nature of this gene.

UR - http://www.scopus.com/inward/record.url?scp=84957978555&partnerID=8YFLogxK

U2 - 10.1128/AAC.00047-15

DO - 10.1128/AAC.00047-15

M3 - Journal article

C2 - 25801555

SN - 0066-4804

VL - 59

SP - 3593

EP - 3595

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus

Abstract

ASJC Scopus subject areas

UN SDGs

More information

Other files and links

Fingerprint

Cite this