Cancer stem cells and their microenvironment: Biology and therapeutic implications

Eunice Yuen Ting Lau, Nicole Pui Yu Ho, Kin Wah Lee

Research output: Journal article publicationReview articleAcademic researchpeer-review

106 Citations (Scopus)


Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance.With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer.
Original languageEnglish
Article number3714190
JournalStem Cells International
Publication statusPublished - 26 Feb 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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