Can probability of genetic mutation be an indicator of clinical relevance?

Chien Lun Chen, Ke Hung Tsui, Chiao Yun Lin, Phei Lang Chang, Petrus Tang, Yat Ming Yung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

NPM1 gene mutation evaluated on a population basis is a valuable and realistic tool to reflect the pathophysiological relevance of cancer. In a comparison of the NPM1 cDNA of human bladder cancer with its consensus sequence, we have found that a higher NPM1 sequence identity in a population is consistent with poor tumor differentiation, advanced tumor stage, and likelihood of recurrence. These data imply that "probability" of NPM1 mutation is an indicator of status of malignancy.
Original languageEnglish
Pages (from-to)746-750
Number of pages5
JournalGenomics
Volume90
Issue number6
DOIs
Publication statusPublished - 1 Dec 2007
Externally publishedYes

Keywords

  • Gene identity
  • Genetic variations
  • Nucleophosmin
  • Population genetics
  • Probability of mutation

ASJC Scopus subject areas

  • Genetics

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