TY - JOUR
T1 - Caloric restriction-mimetics for the reduction of heart failure risk in aging heart
T2 - with consideration of gender-related differences
AU - Pang, Lei
AU - Jiang, Xi
AU - Lian, Xin
AU - Chen, Jie
AU - Song, Er Fei
AU - Jin, Lei Gang
AU - Xia, Zheng Yuan
AU - Ma, Hai Chun
AU - Cai, Yin
N1 - Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (81800245, 81970228, 82102306, 81900779), the China Postdoctoral Science Foundation (2020M670030ZX), the Shaoguan Science and Technology Program (2019sn078), and the Start-up Fund for RAPs under the Strategic Hiring Scheme (P0035913).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This is achieved by preventing cardiac hypertrophy and protecting blood vessels through improving the function of endothelium. However, do these interventions work in the aged human hearts? Cardiac aging is accompanied by an increase in left ventricular hypertrophy, along with diastolic and systolic dysfunction. It also confers significant cardiovascular risks for both sexes. The incidence and prevalence of CVD increase sharply at an earlier age in men than women. Furthermore, the patterns of heart failure differ between sexes, as do the lifetime risk factors. Do caloric restriction (CR)-mimetics, rich in polyphenol or polyamine, delay or reverse cardiac aging equally in both men and women? This review will discuss three areas: (1) mechanisms underlying age-related cardiac remodeling; (2) gender-related differences and potential mechanisms underlying diminished cardiac response in older men and women; (3) we select a few polyphenol or polyamine rich compounds as the CR-mimetics, such as resveratrol, quercetin, curcumin, epigallocatechin gallate and spermidine, due to their capability to extend health-span and induce autophagy. We outline their abilities and issues on retarding aging in animal hearts and preventing CVD in humans. We discuss the confounding factors that should be considered for developing therapeutic strategies against cardiac aging in humans.
AB - The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This is achieved by preventing cardiac hypertrophy and protecting blood vessels through improving the function of endothelium. However, do these interventions work in the aged human hearts? Cardiac aging is accompanied by an increase in left ventricular hypertrophy, along with diastolic and systolic dysfunction. It also confers significant cardiovascular risks for both sexes. The incidence and prevalence of CVD increase sharply at an earlier age in men than women. Furthermore, the patterns of heart failure differ between sexes, as do the lifetime risk factors. Do caloric restriction (CR)-mimetics, rich in polyphenol or polyamine, delay or reverse cardiac aging equally in both men and women? This review will discuss three areas: (1) mechanisms underlying age-related cardiac remodeling; (2) gender-related differences and potential mechanisms underlying diminished cardiac response in older men and women; (3) we select a few polyphenol or polyamine rich compounds as the CR-mimetics, such as resveratrol, quercetin, curcumin, epigallocatechin gallate and spermidine, due to their capability to extend health-span and induce autophagy. We outline their abilities and issues on retarding aging in animal hearts and preventing CVD in humans. We discuss the confounding factors that should be considered for developing therapeutic strategies against cardiac aging in humans.
KW - Caloric restriction
KW - Caloric restriction-mimetics
KW - Cardiac aging
KW - Cardiovascular disease
KW - Clinical application
KW - Dietary compounds
KW - Gender difference
UR - http://www.scopus.com/inward/record.url?scp=85133293278&partnerID=8YFLogxK
U2 - 10.1186/s40779-022-00389-w
DO - 10.1186/s40779-022-00389-w
M3 - Review article
C2 - 35786219
AN - SCOPUS:85133293278
SN - 2095-7467
VL - 9
JO - Military Medical Research
JF - Military Medical Research
IS - 1
M1 - 33
ER -