Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences

Lei Pang, Xi Jiang, Xin Lian, Jie Chen, Er Fei Song, Lei Gang Jin, Zheng Yuan Xia, Hai Chun Ma, Yin Cai

Research output: Journal article publicationReview articleAcademic researchpeer-review

12 Citations (Scopus)


The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This is achieved by preventing cardiac hypertrophy and protecting blood vessels through improving the function of endothelium. However, do these interventions work in the aged human hearts? Cardiac aging is accompanied by an increase in left ventricular hypertrophy, along with diastolic and systolic dysfunction. It also confers significant cardiovascular risks for both sexes. The incidence and prevalence of CVD increase sharply at an earlier age in men than women. Furthermore, the patterns of heart failure differ between sexes, as do the lifetime risk factors. Do caloric restriction (CR)-mimetics, rich in polyphenol or polyamine, delay or reverse cardiac aging equally in both men and women? This review will discuss three areas: (1) mechanisms underlying age-related cardiac remodeling; (2) gender-related differences and potential mechanisms underlying diminished cardiac response in older men and women; (3) we select a few polyphenol or polyamine rich compounds as the CR-mimetics, such as resveratrol, quercetin, curcumin, epigallocatechin gallate and spermidine, due to their capability to extend health-span and induce autophagy. We outline their abilities and issues on retarding aging in animal hearts and preventing CVD in humans. We discuss the confounding factors that should be considered for developing therapeutic strategies against cardiac aging in humans.

Original languageEnglish
Article number33
JournalMilitary Medical Research
Issue number1
Publication statusPublished - Dec 2022


  • Caloric restriction
  • Caloric restriction-mimetics
  • Cardiac aging
  • Cardiovascular disease
  • Clinical application
  • Dietary compounds
  • Gender difference

ASJC Scopus subject areas

  • General Medicine


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