Calcium phosphate nanoparticle-based systems for therapeutic delivery

Yun Piao; Ho Pan Bei; Allison Tam; Yuhe Yang; Qiang Zhang; Mo Yang; Xin Zhao

doi:10.1016/B978-0-12-815341-3.00006-7

Calcium phosphate nanoparticle-based systems for therapeutic delivery

Yun Piao, Ho Pan Bei, Allison Tam, Yuhe Yang, Qiang Zhang, Mo Yang, Xin Zhao

Research output: Chapter in book / Conference proceeding › Chapter in an edited book (as author) › Academic research › peer-review

3 Citations (Scopus)

Abstract

There is great interest in fabricating versatile vehicles with controllable and/or targeted delivery of drugs, genes, and proteins for the improvement of cures for diseases. Calcium phosphates (CaPs), the most widely used bone substitutes in bone tissue engineering, have become one of the most attractive candidates as drug carriers due to their outstanding qualities such as their high bioactivity, biocompatibility, chemical stability, and strong adsorption abilities under physiological conditions. This chapter reviews various types of CaP nanoparticles (NPs) (core-shell, multilayer, lipid- and polymer-coated, etc.) based on their structural differences and their applications in the treatment of diverse diseases, and the factors influencing both the drug-loading and release capacity of CaP NPs.

Original language	English
Title of host publication	Theranostic Bionanomaterials
Publisher	Elsevier
Pages	147-164
Number of pages	18
ISBN (Electronic)	9780128153413
ISBN (Print)	9780128153420
DOIs	https://doi.org/10.1016/B978-0-12-815341-3.00006-7
Publication status	Published - 1 Jan 2019

Keywords

Calcium phosphates
Cellular uptake
Controlled release
Drug delivery
Nanoparticles

ASJC Scopus subject areas

General Medicine
General Biochemistry,Genetics and Molecular Biology

More information

10.1016/B978-0-12-815341-3.00006-7

Cite this

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AU - Bei, Ho Pan

AU - Tam, Allison

AU - Yang, Yuhe

AU - Zhang, Qiang

AU - Yang, Mo

AU - Zhao, Xin

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AB - There is great interest in fabricating versatile vehicles with controllable and/or targeted delivery of drugs, genes, and proteins for the improvement of cures for diseases. Calcium phosphates (CaPs), the most widely used bone substitutes in bone tissue engineering, have become one of the most attractive candidates as drug carriers due to their outstanding qualities such as their high bioactivity, biocompatibility, chemical stability, and strong adsorption abilities under physiological conditions. This chapter reviews various types of CaP nanoparticles (NPs) (core-shell, multilayer, lipid- and polymer-coated, etc.) based on their structural differences and their applications in the treatment of diverse diseases, and the factors influencing both the drug-loading and release capacity of CaP NPs.

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Calcium phosphate nanoparticle-based systems for therapeutic delivery

Abstract

Keywords

ASJC Scopus subject areas

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