Calcium phosphate nanoparticle-based systems for therapeutic delivery

Yun Piao, Ho Pan Bei, Allison Tam, Yuhe Yang, Qiang Zhang, Mo Yang, Xin Zhao

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

2 Citations (Scopus)


There is great interest in fabricating versatile vehicles with controllable and/or targeted delivery of drugs, genes, and proteins for the improvement of cures for diseases. Calcium phosphates (CaPs), the most widely used bone substitutes in bone tissue engineering, have become one of the most attractive candidates as drug carriers due to their outstanding qualities such as their high bioactivity, biocompatibility, chemical stability, and strong adsorption abilities under physiological conditions. This chapter reviews various types of CaP nanoparticles (NPs) (core-shell, multilayer, lipid- and polymer-coated, etc.) based on their structural differences and their applications in the treatment of diverse diseases, and the factors influencing both the drug-loading and release capacity of CaP NPs.

Original languageEnglish
Title of host publicationTheranostic Bionanomaterials
Number of pages18
ISBN (Electronic)9780128153413
ISBN (Print)9780128153420
Publication statusPublished - 1 Jan 2019


  • Calcium phosphates
  • Cellular uptake
  • Controlled release
  • Drug delivery
  • Nanoparticles

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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