Bulky Phosphane Ligand for Monoselective Ruthenium-Catalyzed, Directed o -C-H Arylation with Challenging Aryl Chlorides

You Gui Li, Zhen Yu Wang, Ya Ling Zou, Chau Ming So, Fuk Yee Kwong, Hua Li Qin, Eric Assen B. Kantchev

Research output: Journal article publicationJournal articleAcademic researchpeer-review

7 Citations (Scopus)

Abstract

Functionalized aryl chlorides are more economically attractive but usually much more difficult as substrates in metal-mediated couplings than the corresponding bromides and iodides. A catalyst prepared from a bulky (biaryl)diphenyl phosphane and a common ruthenium source (1:1) mediates selective direct monoarylations of arenes bearing 2-pyridyl and related ortho-directing groups in good yields. Sequential arylations to heterodiarylated products also proceed in satisfactory yields.
Original languageEnglish
Article numberst-2016-w0553-l
Pages (from-to)499-503
Number of pages5
JournalSynlett
Volume28
Issue number4
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • aryl chlorides
  • arylations
  • C-H activation
  • heterocycles
  • phosphanes
  • ruthenium

ASJC Scopus subject areas

  • Organic Chemistry

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