Abstract
This study describes the efficacy of benzimidazolyl phosphine ligands, which are easily synthesized from inexpensive and commercially available o-phenylenediamine, 2-bormobenzoic acid, and chlorophosphines, in the Buchwald-Hartwig amination of aryl chlorides. Primary and secondary aromatic/aliphatic amines are effective substrates in this catalytic system. Functional groups such as keto and esters are also compatible. The catalyst loading can be reduced to 0.1 mol% Pd.
Original language | English |
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Pages (from-to) | 1181-1186 |
Number of pages | 6 |
Journal | Synlett |
Volume | 23 |
Issue number | 8 |
DOIs | |
Publication status | Published - 27 Apr 2012 |
Keywords
- amination
- aryl chlorides
- cross-coupling
- palladium
- phosphine
ASJC Scopus subject areas
- Organic Chemistry