Buchwald-Hartwig amination of aryl chlorides catalyzed by easily accessible benzimidazolyl phosphine-Pd complexes

Kin Ho Chung, Chau Ming So, Shun Man Wong, Chi Him Luk, Zhongyuan Zhou, Chak Po Lau, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

23 Citations (Scopus)


This study describes the efficacy of benzimidazolyl phosphine ligands, which are easily synthesized from inexpensive and commercially available o-phenylenediamine, 2-bormobenzoic acid, and chlorophosphines, in the Buchwald-Hartwig amination of aryl chlorides. Primary and secondary aromatic/aliphatic amines are effective substrates in this catalytic system. Functional groups such as keto and esters are also compatible. The catalyst loading can be reduced to 0.1 mol% Pd.
Original languageEnglish
Pages (from-to)1181-1186
Number of pages6
Issue number8
Publication statusPublished - 27 Apr 2012


  • amination
  • aryl chlorides
  • cross-coupling
  • palladium
  • phosphine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this