Broad-Spectrum Antimicrobial Polymer with Dual Bactericidal Mechanisms Enhances Antibiotic Activity in the Treatment of Fish Infections

Yue Yu, Xianhui Chen, Huangsheng Pu, Min Wang, Junfeng Song, Anming Yang, Muyang Wan, Yugang Bai, Qinyun Cai, Junfa Yuan, Chunhui Zhang, Wing Leung Wong, Xinxin Feng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Bacterial infection in aquaculture farming has been a well-known issue, and the situation is worsened by the limitations on antibiotic usage due to environmental considerations. This study reports the design and synthesis of a broad-spectrum antimicrobial polymer, PC3-8, demonstrated for the first time as an efficient antimicrobial agent against a number of common fish pathogens, including Gram-positive and Gram-negative ones. A dual-bactericidal mechanism is proposed for PC3-8, in which the cationic polymer is found to disrupt bacterial membranes and interact with genome DNA, effectively causing bacterial cell death. PC3-8 is capable of eliminating pathogens in mammalian cell cultures, preventing them from being killed by those pathogens. When PC3-8 was applied into water, it healed bacteria-infected zebrafish, outperforming common antibiotics, such as Kanamycin and Chloramphenicol. Importantly, PC3-8 possesses low drug resistance emergence and potent synergistic effects with commercial antibiotics. Therefore, it shows great effectiveness against resistant pathogens and evades any potential environmental risk related to resistance generation. The present study demonstrates that PC3-8 is a promising antimicrobial agent for treating bacterial infection related fish diseases and has potential applications in the aquaculture industry.

Original languageEnglish
Pages (from-to)8618-8628
Number of pages11
JournalACS Applied Polymer Materials
Volume6
Issue number14
DOIs
Publication statusPublished - 26 Jul 2024

Keywords

  • antimicrobial mechanism
  • antimicrobial polymers
  • fish pathogens
  • multiple targeting
  • synergistic combination

ASJC Scopus subject areas

  • Process Chemistry and Technology
  • Polymers and Plastics
  • Organic Chemistry

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