Brevilin a, a natural sesquiterpene lactone inhibited the growth of triple-negative breast cancer cells via Akt/mTOR and STAT3 signaling pathways

Keyphrases

• STAT3 Signaling Pathway 100%
• Triple-negative Breast Cancer Cells 100%
• PI3K-AKT-mTOR Pathway 100%
• Brevilin A 100%
• Sesquiterpene Lactones 100%
• Triple-negative Breast Cancer 36%
• Apoptosis 27%
• Cell Cycle Arrest 18%
• Mammalian Target of Rapamycin (mTOR) 18%
• Oral Administration 9%
• Inhibitory Effect 9%
• Breast Cancer 9%
• Signaling Pathway 9%
• Western Blot Analysis 9%
• Protein Expression 9%
• Phosphorylation 9%
• Flow Cytometry 9%
• Cell Viability 9%
• Cell Migration 9%
• High Efficacy 9%
• Breast Cancer Cell Lines 9%
• M Phase Arrest 9%
• MTT Assay 9%
• Estrogen Receptor 9%
• Anticancer Effect 9%
• Anticancer Activity 9%
• Poor Prognosis 9%
• Anticancer Agents 9%
• Xenograft Mouse Model 9%
• Anticancer Therapeutics 9%
• Xenograft Mice 9%
• Tumor Cell Migration 9%
• Human Epidermal Growth Factor Receptor 2 (HER2) 9%
• Progesterone Receptor 9%
• Breast Cancer Subtypes 9%
• Cancer Effects 9%
• Cancer Therapeutic Drug 9%
• Wound Healing Assay 9%
• Tumor Proliferation 9%
• Orthotopic Tumor Xenograft 9%
• Tumor Xenograft Model 9%
• Tumor Inhibition 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Triple Negative Breast Cancer 100%
• Sesquiterpene Lactone 100%
• Malignant Neoplasm 37%
• Neoplasm 37%
• Mouse Model 25%
• Tumor Growth 25%
• Breast Cancer 25%
• STAT3 Protein 25%
• Western Blot 12%
• Flow Cytometry 12%
• Cell Viability 12%
• Anticarcinogen 12%
• Receptor 12%
• Wound Healing 12%
• Estrogen Receptor 12%
• Progesterone Receptor 12%