Bone regeneration strategy inspired by the study of calcification behavior in deer antler

Haishan Shi, Tao Yu, Zhaoyang Li, William Lu, Ming Zhang, Jiandong Ye

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)


Bone regeneration has attracted much attention from various researchers and inspired numerous strategies for bone formation. In this study, rapid calcification of deer antlers was studied to unravel bone biology by investigating mineral composition, morphology and microstructure. Calcification model was hypothesized and preliminarily established by in vitro experiments. In our model, mineral deposition and phase conversions in the gel matrix were mimicked. Results revealed that mineral metabolism including deposition and phase conversion plays key roles in calcification in vivo, which inspired the bone regeneration strategy with three main components, i.e. enhanced mineral nucleation, mineral ions sources and crystals habits. Rapid mineral metabolism of implant apatite biomaterials was supposed as the critical aspect of bone regeneration. This study will provide a relatively ideal model for peer bone regeneration studies.
Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalMaterials Science and Engineering C
Publication statusPublished - 30 Jul 2015


  • Antler
  • Biomineralization
  • Bone regeneration
  • Calcification

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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