Bond formation of surface-tethered receptor-ligand pairs in relative separation

Jin Qian, Yuan Lin, Hongyuan Jiang, Haimin Yao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)

Abstract

We theoretically and numerically investigate the interplay between diffusion of a surface-bound receptor and its reaction with an opposing ligand. Special attention has been paid to the mechanical regulation of bond association by varying the initial gap distance and relative separation speed between the protein-bearing surfaces. Such diffusion-reaction coupling effects can cause the apparent on-rate or reciprocal of the average waiting time for bond formation, to be not constant, but instead a function sensitive to the system parameters that affect the transport of proteins. The results provide a quantitative understanding of how significantly the transport mechanism can affect overall binding behavior of molecular interactions and call for a paradigm shift in modeling receptor-ligand bond association when the protein-bearing surfaces are in relative separation.
Original languageEnglish
Article number223702
JournalApplied Physics Letters
Volume103
Issue number22
DOIs
Publication statusPublished - 25 Nov 2013

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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