TY - JOUR
T1 - Birth weight and prematurity with lung function at ~17.5 years
T2 - “Children of 1997” birth cohort
AU - He, Baoting
AU - Kwok, Man Ki
AU - Au Yeung, Shiu Lun
AU - Lin, Shi Lin
AU - Leung, June Yue Yan
AU - Hui, Lai Ling
AU - Li, Albert M.
AU - Leung, Gabriel M.
AU - Schooling, C. Mary
N1 - Funding Information:
We thank the late Dr. Connie O for coordinating the project and all the fieldwork for the initial study in 1997–98. This work is a sub-study of the “Children of 1997” birth cohort which was initially supported by the Health Care and Promotion Fund, Health and Welfare Bureau, Government of the Hong Kong Special Administrative Region [HCPF Grant # 216106] and re-established in 2005 funded by the Health and Health Services Research Fund [HHSRF Grant # 03040771, 05060671, 07080751, 07080841] and the Research Fund for the Control of Infectious Diseases in Hong Kong (RFCID Grant # 04050172, 06060592), Government of the Hong Kong SAR. The birth cohort has also received funding from the University Research Committee Strategic Research Theme of Public Health Granted Research, The University of Hong Kong. The most recent follow-up was partly funded by the WYNG Foundation.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong’s “Children of 1997” birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF25–75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV1/FVC and FEF25–75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness.
AB - We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong’s “Children of 1997” birth cohort, adjusted associations of prematurity and birth weight with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75%) at ~17.5 years were assessed. Associations for birth weight were stronger in boys for FEV1 (boys: 0.31 L, 95% confidence interval (CI) 0.24 to 0.38, girls: 0.18 L, 95% CI 0.12 to 0.25), FVC (boys: 0.36 L, 95% CI 0.27 to 0.44, girls: 0.22 L, 95% CI 0.15 to 0.28) and FEF25–75% (boys: 0.35 L, 95% CI 0.21 to 0.49, girls: 0.22 L, 95% CI 0.09 to 0.34) adjusted for age, socioeconomic position and infant and maternal characteristics. Similarly adjusted, preterm birth (compared to full-term birth) was associated with lower FEV1/FVC and FEF25–75%. Thus, associations of lower birth weight, especially in boys, and prematurity with poorer lung function at 17.5 years were found. Identifying underlying mechanism might contribute to the improvement of pulmonary health and the prevention of adult respiratory illness.
UR - http://www.scopus.com/inward/record.url?scp=85077942096&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-56086-7
DO - 10.1038/s41598-019-56086-7
M3 - Journal article
C2 - 31941940
AN - SCOPUS:85077942096
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 341
ER -