Biosensor based on fluorescent spherical resonator using polystyrene microbead

Y. F. Yu, T. Bourouina, Z. X. Shen, N. Q. Ngo, A. Q. Liu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

This paper presents an on-chip biosensor using a polystyrene fluorescent microsphere as an optical resonator to enhance the fluorescence emission. The microsphere is attached on the wall of a microchannel in a polydimethylsiloxane (PDMS) optofluidic chip and excited by a focused laser beam using a confocal Raman microscope system. Based on the shift of Whispering Gallery modes (WGMs), this sensor has a resolution of 0.1% for protein concentration detection. Combined with the micro-opto-fluidic-system (MOFS), the biosensor has the advantage of tiny volume detection and high resolution, which shows promise in many applications such as real time biological analysis and environmental monitoring.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1253-1255
Number of pages3
Publication statusPublished - Oct 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Biosensors
  • Micro-opto-fluidic-system (MOFS)
  • Microsphere
  • Protein concentration

ASJC Scopus subject areas

  • Control and Systems Engineering

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