Biophysical characterization of hematopoietic cells from normal and leukemic sources with distinct primitiveness

Youhua Tan, Tsz Kan Fung, Haixia Wan, Kaiqun Wang, Anskar Y.H. Leung, Dong Sun

Research output: Journal article publicationJournal articleAcademic researchpeer-review

28 Citations (Scopus)


This letter reported the biophysical characterization of immunophenotypically distinct hematopoietic cells from normal and leukemic sources, through manipulation with optical tweezers at single cell level. The results show that the percentage of cells that are stretchable and their deformability are significantly higher in the more primitive cell populations. This study provides the evidence that normal and leukemic hematopoietic cell populations with distinct primitiveness exhibit differential biophysical properties. These findings raise a hypothesis that the high deformability may be related to the unique functions and activities of primitive hematopoietic cells.
Original languageEnglish
Article number083702
JournalApplied Physics Letters
Issue number8
Publication statusPublished - 22 Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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