Bionanofibers in drug delivery

Xin Zhao, Lara Yildirimer, Zhi Yuan William Lin, Wenguo Cui

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

Abstract

Their high surface area, open porosity, and adjustable pore size render nanofibers a distinct class of candidates suitable for site-specific controlled drug delivery. Bionanofibers can be fabricated using numerous types of polymers, both synthetic and natural, with various techniques. Currently, the three major techniques employed to fabricate nanofibers are (1) electrospinning, (2) self-assembly, and (3) temperature-induced phase separation with electrospinning being the most popular. For therapeutic purposes, different types of drugs, growth factors, and genes may be either internalized within the nanofibers or surface-conjugated. Due to the versatility of drugs being used, these drug-loaded nanofibers can be utilized in many clinical applications including cutaneous wound dressing, cancer drug delivery, and inhibition of scar formation as well as reconstruction of various tissues. This chapter entails information about nanofibers fabricated by different techniques as well as their applications in drug delivery and tissue regeneration.
Original languageEnglish
Title of host publicationNanobiomaterials in Drug Delivery
Subtitle of host publicationApplications of Nanobiomaterials
PublisherElsevier Inc.
Pages403-445
Number of pages43
ISBN (Electronic)9780323428897
ISBN (Print)9780323428668
DOIs
Publication statusPublished - 16 May 2016
Externally publishedYes

Keywords

  • Drug delivery
  • Electrospinning
  • Nanofibers
  • Self-assembly
  • Temperature-induced phase separation
  • Tissue engineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

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