Biomimicking Nano-Micro Binary Polymer Brushes for Smart Cell Orientation and Adhesion Control

Lina Chen, Zhuang Xie, Tiansheng Gan, Yi Wang, Guangzhao Zhang, Chad A. Mirkin, Zijian Zheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

37 Citations (Scopus)


KGaA, Weinheim. A new biomimetic surface named nano-micro binary polymer brushes is fabricated by large-area bench-top dip-pen nanodisplacement lithography technique. It is composed of gelatin-modified poly(glycidyl methacrylate) nanolines which are spaced by microstripes of poly(N-isopropylacrylamide). Cells are not only adhered and oriented well on the re-used surface, but also detachable from the surface with well-preserved extracellular matrix and aligned morphology.
Original languageEnglish
Pages (from-to)3400-3406
Number of pages7
JournalSmall (Weinheim an der Bergstrasse, Germany)
Issue number25
Publication statusPublished - 1 Jul 2016


  • bio-nano interfaces
  • cell adhesion
  • cell orientation
  • dip-pen nanolithography
  • polymer brushes

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Engineering (miscellaneous)

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