Biomimicking Nano-Micro Binary Polymer Brushes for Smart Cell Orientation and Adhesion Control

Lina Chen; Zhuang Xie; Tiansheng Gan; Yi Wang; Guangzhao Zhang; Chad A. Mirkin; Zijian Zheng

doi:10.1002/smll.201600634

Biomimicking Nano-Micro Binary Polymer Brushes for Smart Cell Orientation and Adhesion Control

Lina Chen, Zhuang Xie, Tiansheng Gan, Yi Wang, Guangzhao Zhang, Chad A. Mirkin, Zijian Zheng

Research output: Journal article publication › Journal article › Academic research › peer-review

43 Citations (Scopus)

Abstract

KGaA, Weinheim. A new biomimetic surface named nano-micro binary polymer brushes is fabricated by large-area bench-top dip-pen nanodisplacement lithography technique. It is composed of gelatin-modified poly(glycidyl methacrylate) nanolines which are spaced by microstripes of poly(N-isopropylacrylamide). Cells are not only adhered and oriented well on the re-used surface, but also detachable from the surface with well-preserved extracellular matrix and aligned morphology.

Original language	English
Pages (from-to)	3400-3406
Number of pages	7
Journal	Small (Weinheim an der Bergstrasse, Germany)
Volume	12
Issue number	25
DOIs	https://doi.org/10.1002/smll.201600634
Publication status	Published - 1 Jul 2016

Keywords

bio-nano interfaces
cell adhesion
cell orientation
dip-pen nanolithography
polymer brushes

ASJC Scopus subject areas

Biotechnology
Biomaterials
Engineering (miscellaneous)

More information

10.1002/smll.201600634

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title = "Biomimicking Nano-Micro Binary Polymer Brushes for Smart Cell Orientation and Adhesion Control",

abstract = "KGaA, Weinheim. A new biomimetic surface named nano-micro binary polymer brushes is fabricated by large-area bench-top dip-pen nanodisplacement lithography technique. It is composed of gelatin-modified poly(glycidyl methacrylate) nanolines which are spaced by microstripes of poly(N-isopropylacrylamide). Cells are not only adhered and oriented well on the re-used surface, but also detachable from the surface with well-preserved extracellular matrix and aligned morphology.",

keywords = "bio-nano interfaces, cell adhesion, cell orientation, dip-pen nanolithography, polymer brushes",

author = "Lina Chen and Zhuang Xie and Tiansheng Gan and Yi Wang and Guangzhao Zhang and Mirkin, {Chad A.} and Zijian Zheng",

year = "2016",

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doi = "10.1002/smll.201600634",

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T1 - Biomimicking Nano-Micro Binary Polymer Brushes for Smart Cell Orientation and Adhesion Control

AU - Chen, Lina

AU - Xie, Zhuang

AU - Gan, Tiansheng

AU - Wang, Yi

AU - Zhang, Guangzhao

AU - Mirkin, Chad A.

AU - Zheng, Zijian

PY - 2016/7/1

Y1 - 2016/7/1

N2 - KGaA, Weinheim. A new biomimetic surface named nano-micro binary polymer brushes is fabricated by large-area bench-top dip-pen nanodisplacement lithography technique. It is composed of gelatin-modified poly(glycidyl methacrylate) nanolines which are spaced by microstripes of poly(N-isopropylacrylamide). Cells are not only adhered and oriented well on the re-used surface, but also detachable from the surface with well-preserved extracellular matrix and aligned morphology.

AB - KGaA, Weinheim. A new biomimetic surface named nano-micro binary polymer brushes is fabricated by large-area bench-top dip-pen nanodisplacement lithography technique. It is composed of gelatin-modified poly(glycidyl methacrylate) nanolines which are spaced by microstripes of poly(N-isopropylacrylamide). Cells are not only adhered and oriented well on the re-used surface, but also detachable from the surface with well-preserved extracellular matrix and aligned morphology.

KW - bio-nano interfaces

KW - cell adhesion

KW - cell orientation

KW - dip-pen nanolithography

KW - polymer brushes

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DO - 10.1002/smll.201600634

M3 - Journal article

C2 - 27184011

SN - 1613-6829

VL - 12

SP - 3400

EP - 3406

JO - Small (Weinheim an der Bergstrasse, Germany)

JF - Small (Weinheim an der Bergstrasse, Germany)

IS - 25

ER -

Biomimicking Nano-Micro Binary Polymer Brushes for Smart Cell Orientation and Adhesion Control

Abstract

Keywords

ASJC Scopus subject areas

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