Abstract
Dynamic controlling the nanoscale presentation of synergistic ligands to stem cells by biomimetic single-chain materials can provide critical insights to understand the molecular crosstalk underlying cells and their extracellular matrix. Here, a stimuli-responsive single-chain macromolecular nanoregulator with conformational dynamics is fabricated based on an advanced scale-up single polymeric chain nanogel (SCNG). Such a carefully designed SCNG is capable of mediating a triggered copresentation of the master and cryptic ligands in a single molecule to elicit the synergistic crosstalk between different intracellular signaling pathways, thereby considerably boosting the bioactivity of the presented ligands. This controllable nanoswitching-on of cell-adhesive ligands' presentation allows the regulation of cell adhesion and fate from molecular scale. The modular nature of this synthetic macromolecular nanoregulator makes it a versatile nanomaterial platform to assist basic and fundamental studies in a wide array of research topics.
| Original language | English |
|---|---|
| Pages (from-to) | 4027-4035 |
| Number of pages | 9 |
| Journal | ACS Nano |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 28 Apr 2020 |
Keywords
- cryptic ligands presentation
- single-chain nanogel
- stem cells regulation
- stimuli-responsive nanoregulator
- synergistic ligands
ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
- Physics and Astronomy(all)