Biomaterials based strategies for rotator cuff repair

Song Zhao, Wei Su, Vishva Shah, Divia Hobson, Lara Yildirimer, Kelvin W.K. Yeung, Jinzhong Zhao, Wenguo Cui, Xin Zhao

Research output: Journal article publicationReview articleAcademic researchpeer-review

18 Citations (Scopus)

Abstract

Tearing of the rotator cuff commonly occurs as among one of the most frequently experienced tendon disorders. While treatment typically involves surgical repair, failure rates to achieve or sustain healing range from 20 to 90%. The insufficient capacity to recover damaged tendon to heal to the bone, especially at the enthesis, is primarily responsible for the failure rates reported. Various types of biomaterials with special structures have been developed to improve tendon-bone healing and tendon regeneration, and have received considerable attention for replacement, reconstruction, or reinforcement of tendon defects. In this review, we first give a brief introduction of the anatomy of the rotator cuff and then discuss various design strategies to augment rotator cuff repair. Furthermore, we highlight current biomaterials used for repair and their clinical applications as well as the limitations in the literature. We conclude this article with challenges and future directions in designing more advanced biomaterials for augmentation of rotator cuff repair.
Original languageEnglish
Pages (from-to)407-416
Number of pages10
JournalColloids and Surfaces B: Biointerfaces
Volume157
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • Biocompatibility
  • Biomaterials
  • Degradation
  • Mechanical properties
  • Rotator cuff regeneration

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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