Biological role of TRPC1 in myogenesis, regeneration, and disease

Wai Ella Yeung, Kwok Kuen Cheung, Keng Ting Sun

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

Abstract

2017. The transient receptor potential canonical (TRPC) family consists of seven isoforms that have been proposed as molecular components essential for nonselective calcium (Ca2+) entry. TRPC1 proteins are expressed in the sarcolemma of skeletal muscles, and TRPC1 is important and necessary for stretch-activated and store-operated channels for Ca2+entry. Studies have established the essential role of TRPC1 in maintaining Ca2+homeostasis, regulating myoblast migration and differentiation, regenerating muscle, and contributing to the pathogenesis of muscular dystrophy. This chapter summarizes the evidence for the regulation of TRPC1 to fulfill specific physiological functions in skeletal muscles.
Original languageEnglish
Title of host publicationThe Plasticity of Skeletal Muscle
Subtitle of host publicationFrom Molecular Mechanism to Clinical Applications
PublisherSpringer Singapore
Pages211-230
Number of pages20
ISBN (Electronic)9789811032929
ISBN (Print)9789811032912
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Calcium
  • Duchenne muscular dystrophy
  • Mechanosensation
  • Muscle regeneration
  • Myogenesis
  • Transient receptor potential canonical type 1

ASJC Scopus subject areas

  • Medicine(all)
  • Engineering(all)

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