Biological role of TRPC1 in myogenesis, regeneration, and disease

Wai Ella Yeung; Kwok Kuen Cheung; Keng Ting Sun

doi:10.1007/978-981-10-3292-9_10

Biological role of TRPC1 in myogenesis, regeneration, and disease

Wai Ella Yeung, Kwok Kuen Cheung, Keng Ting Sun

Research output: Chapter in book / Conference proceeding › Chapter in an edited book (as author) › Academic research › peer-review

Abstract

2017. The transient receptor potential canonical (TRPC) family consists of seven isoforms that have been proposed as molecular components essential for nonselective calcium (Ca2+) entry. TRPC1 proteins are expressed in the sarcolemma of skeletal muscles, and TRPC1 is important and necessary for stretch-activated and store-operated channels for Ca2+entry. Studies have established the essential role of TRPC1 in maintaining Ca2+homeostasis, regulating myoblast migration and differentiation, regenerating muscle, and contributing to the pathogenesis of muscular dystrophy. This chapter summarizes the evidence for the regulation of TRPC1 to fulfill specific physiological functions in skeletal muscles.

Original language	English
Title of host publication	The Plasticity of Skeletal Muscle
Subtitle of host publication	From Molecular Mechanism to Clinical Applications
Publisher	Springer Singapore
Pages	211-230
Number of pages	20
ISBN (Electronic)	9789811032929
ISBN (Print)	9789811032912
DOIs	https://doi.org/10.1007/978-981-10-3292-9_10
Publication status	Published - 1 Jan 2017

Keywords

Calcium
Duchenne muscular dystrophy
Mechanosensation
Muscle regeneration
Myogenesis
Transient receptor potential canonical type 1

ASJC Scopus subject areas

General Medicine
General Engineering

More information

10.1007/978-981-10-3292-9_10

Cite this

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Biological role of TRPC1 in myogenesis, regeneration, and disease. / Yeung, Wai Ella; Cheung, Kwok Kuen; Sun, Keng Ting.
The Plasticity of Skeletal Muscle: From Molecular Mechanism to Clinical Applications. Springer Singapore, 2017. p. 211-230.

Research output: Chapter in book / Conference proceeding › Chapter in an edited book (as author) › Academic research › peer-review

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Biological role of TRPC1 in myogenesis, regeneration, and disease

Abstract

Keywords

ASJC Scopus subject areas

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