TY - JOUR
T1 - Bioinspired Polymeric Coating with Self-Adhesion, Lubrication, and Drug Release for Synergistic Bacteriostatic and Bactericidal Performance
AU - Wang, Haimang
AU - Yang, Yuhe
AU - Zhao, Weiwei
AU - Han, Ying
AU - Luo, Jing
AU - Zhao, Xin
AU - Zhang, Hongyu
N1 - Funding Information:
H.W. and Y.Y. contributed equally to this work. This study was financially supported by National Natural Science Foundation of China (52022043, 82122002), Tsinghua University–Peking Union Medical College Hospital Initiative Scientific Research Program (20191080593), Precision Medicine Foundation, Tsinghua University, China (10001020120), Capital's Funds for Health Improvement and Research (2020‐2Z‐40810), Research Fund of State Key Laboratory of Tribology, Tsinghua University, China (SKLT2022C18) and Shenzhen Basic Research Project, Shenzhen Science and Technology Innovation Committee (2021Szvup141).
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/9/13
Y1 - 2022/9/13
N2 - A combination of surface lubrication and antibacterial performance is highly imperative for biomedical implants in clinic. In this study, motivated by mussel-inspired adhesion, articular cartilage superlubrication, and drug-loading capacity of cyclodextrins, a new copolymer of p(DMA-MPC-CD) (namely PDMC) with self-adhesion, lubrication, and drug loading & release properties is developed for fabricating a versatile platform to construct a synergistic bacteriostatic/bactericidal surface. Specifically, the biomimetic coating is prepared via polydopamine mediated layer-by-layer (LBL) self-assembly method on the surface of titanium alloy (Ti6Al4V), and characterized by quartz crystal microbalance, X-ray photoelectron spectroscopy, and surface wettability to confirm the modification process. The biocompatibility evaluation using L929 cells shows that the coating, even with pre-loaded bactericide, presents satisfied biocompatibility in vitro. Additionally, the enhanced lubrication and bacterial resistance properties of copolymer-coated Ti6Al4V (Ti6Al4V@PDMC) are attributed to the tenacious hydration shell that is formed surrounding the zwitterionic phosphorylcholine charges. Furthermore, the bactericidal function of the biomimetic coating is successfully achieved by releasing the pre-loaded bactericide in a sustained manner, which effectively kills the adhered bacteria on the surface. In summary, the bioinspired surface functionalization strategy developed here may act as a universal and promising method for achieving enhanced lubrication and synergistic bacteriostatic/bactericidal properties in biomedical implants.
AB - A combination of surface lubrication and antibacterial performance is highly imperative for biomedical implants in clinic. In this study, motivated by mussel-inspired adhesion, articular cartilage superlubrication, and drug-loading capacity of cyclodextrins, a new copolymer of p(DMA-MPC-CD) (namely PDMC) with self-adhesion, lubrication, and drug loading & release properties is developed for fabricating a versatile platform to construct a synergistic bacteriostatic/bactericidal surface. Specifically, the biomimetic coating is prepared via polydopamine mediated layer-by-layer (LBL) self-assembly method on the surface of titanium alloy (Ti6Al4V), and characterized by quartz crystal microbalance, X-ray photoelectron spectroscopy, and surface wettability to confirm the modification process. The biocompatibility evaluation using L929 cells shows that the coating, even with pre-loaded bactericide, presents satisfied biocompatibility in vitro. Additionally, the enhanced lubrication and bacterial resistance properties of copolymer-coated Ti6Al4V (Ti6Al4V@PDMC) are attributed to the tenacious hydration shell that is formed surrounding the zwitterionic phosphorylcholine charges. Furthermore, the bactericidal function of the biomimetic coating is successfully achieved by releasing the pre-loaded bactericide in a sustained manner, which effectively kills the adhered bacteria on the surface. In summary, the bioinspired surface functionalization strategy developed here may act as a universal and promising method for achieving enhanced lubrication and synergistic bacteriostatic/bactericidal properties in biomedical implants.
KW - dopamine
KW - hydration lubrication
KW - phosphorylcholine coating
KW - self-assembly
KW - surface functionalization
UR - http://www.scopus.com/inward/record.url?scp=85132586413&partnerID=8YFLogxK
U2 - 10.1002/admi.202200561
DO - 10.1002/admi.202200561
M3 - Journal article
AN - SCOPUS:85132586413
SN - 2196-7350
VL - 9
JO - Advanced Materials Interfaces
JF - Advanced Materials Interfaces
IS - 26
M1 - 2200561
ER -